3v00
From Proteopedia
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| - | {{STRUCTURE_3v00| PDB=3v00 | SCENE= }} | ||
| - | ===Studies of a constitutively active G-alpha subunit provide insights into the mechanism of G protein activation.=== | ||
| - | {{ABSTRACT_PUBMED_22448927}} | ||
| - | == | + | ==Studies of a constitutively active G-alpha subunit provide insights into the mechanism of G protein activation.== |
| - | [[http://www.uniprot.org/uniprot/GNAT1_BOVIN GNAT1_BOVIN | + | <StructureSection load='3v00' size='340' side='right'caption='[[3v00]], [[Resolution|resolution]] 2.90Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3v00]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V00 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v00 OCA], [https://pdbe.org/3v00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v00 RCSB], [https://www.ebi.ac.uk/pdbsum/3v00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v00 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GNAT1_BOVIN GNAT1_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Transducin 3D structures|Transducin 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Rattus norvegicus]] |
| - | [[Category: | + | [[Category: Cerione RA]] |
| - | [[Category: | + | [[Category: Singh G]] |
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Current revision
Studies of a constitutively active G-alpha subunit provide insights into the mechanism of G protein activation.
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