4fev

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{{STRUCTURE_4fev| PDB=4fev | SCENE= }}
 
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===Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP1===
 
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{{ABSTRACT_PUBMED_23758273}}
 
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==About this Structure==
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==Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP1==
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[[4fev]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii_aye Acinetobacter baumannii aye]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEV OCA].
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<StructureSection load='4fev' size='340' side='right'caption='[[4fev]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fev]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_AYE Acinetobacter baumannii AYE]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FEV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=KAN:KANAMYCIN+A'>KAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PP1:1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE'>PP1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fev OCA], [https://pdbe.org/4fev PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fev RCSB], [https://www.ebi.ac.uk/pdbsum/4fev PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fev ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B0VD92_ACIBY B0VD92_ACIBY]
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==Reference==
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==See Also==
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<ref group="xtra">PMID:023758273</ref><references group="xtra"/><references/>
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*[[Phosphotransferase 3D structures|Phosphotransferase 3D structures]]
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[[Category: Acinetobacter baumannii aye]]
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__TOC__
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[[Category: Kanamycin kinase]]
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</StructureSection>
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[[Category: Anderson, W F.]]
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[[Category: Acinetobacter baumannii AYE]]
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[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
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[[Category: Large Structures]]
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[[Category: Egorova, O.]]
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[[Category: Anderson WF]]
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[[Category: Evdokimova, E.]]
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[[Category: Di Leo R]]
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[[Category: Leo, R Di.]]
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[[Category: Egorova O]]
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[[Category: Minasov, G.]]
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[[Category: Evdokimova E]]
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[[Category: Savchenko, A.]]
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[[Category: Minasov G]]
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[[Category: Shakya, T.]]
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[[Category: Savchenko A]]
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[[Category: Spanogiannopoulos, P.]]
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[[Category: Shakya T]]
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[[Category: Stogios, P J.]]
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[[Category: Spanogiannopoulos P]]
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[[Category: Wawrzak, Z.]]
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[[Category: Stogios PJ]]
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[[Category: Wright, G D.]]
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[[Category: Wawrzak Z]]
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[[Category: Alpha/beta protein]]
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[[Category: Wright GD]]
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[[Category: Aminoglycoside phosphotransferase]]
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[[Category: Aminoglycoside]]
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[[Category: Antibiotic resistance]]
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[[Category: Center for structural genomics of infectious disease]]
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[[Category: Csgid]]
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[[Category: Eukaryotic protein kinase-like fold]]
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[[Category: Gtp]]
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[[Category: Intracellular]]
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[[Category: Kanamycin]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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[[Category: Phosphotransferase]]
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[[Category: Pp1]]
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[[Category: Protein kinase inhibitor]]
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[[Category: Pyrazolopyrimidine]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP1

PDB ID 4fev

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