3qfx
From Proteopedia
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| - | {{STRUCTURE_3qfx| PDB=3qfx | SCENE= }} | ||
| - | ===Trypanosoma brucei dihydrofolate reductase pyrimethamine complex=== | ||
| - | {{ABSTRACT_PUBMED_21650210}} | ||
| - | == | + | ==Trypanosoma brucei dihydrofolate reductase pyrimethamine complex== |
| - | [[3qfx]] is a 2 chain structure with sequence from [ | + | <StructureSection load='3qfx' size='340' side='right'caption='[[3qfx]], [[Resolution|resolution]] 2.20Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3qfx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_rhodesiense Trypanosoma brucei rhodesiense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QFX FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qfx OCA], [https://pdbe.org/3qfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qfx RCSB], [https://www.ebi.ac.uk/pdbsum/3qfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qfx ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DRTS_TRYBB DRTS_TRYBB] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity). | ||
| - | == | + | ==See Also== |
| - | + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Trypanosoma brucei rhodesiense]] | [[Category: Trypanosoma brucei rhodesiense]] | ||
| - | [[Category: Chitnumsub | + | [[Category: Chitnumsub P]] |
| - | [[Category: Kamchonwongpaisan | + | [[Category: Kamchonwongpaisan S]] |
| - | [[Category: Taweechai | + | [[Category: Taweechai S]] |
| - | [[Category: Vanichtanankul | + | [[Category: Vanichtanankul J]] |
| - | [[Category: Yuthavong | + | [[Category: Yuthavong Y]] |
| - | [[Category: Yuvaniyama | + | [[Category: Yuvaniyama J]] |
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Current revision
Trypanosoma brucei dihydrofolate reductase pyrimethamine complex
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