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4kfo

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{{STRUCTURE_4kfo| PDB=4kfo | SCENE= }}
 
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===Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors===
 
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{{ABSTRACT_PUBMED_23617784}}
 
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==Function==
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==Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors==
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[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
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<StructureSection load='4kfo' size='340' side='right'caption='[[4kfo]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4kfo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KFO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1QS:N-{4-[(3,5-DIFLUOROPHENYL)SULFONYL]BENZYL}IMIDAZO[1,2-A]PYRIDINE-6-CARBOXAMIDE'>1QS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kfo OCA], [https://pdbe.org/4kfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kfo RCSB], [https://www.ebi.ac.uk/pdbsum/4kfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kfo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
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==About this Structure==
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==See Also==
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[[4kfo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFO OCA].
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:023617784</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Nicotinamide phosphoribosyltransferase]]
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[[Category: Large Structures]]
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[[Category: Bair, K W.]]
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[[Category: Bair KW]]
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[[Category: Bauer, P.]]
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[[Category: Bauer P]]
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[[Category: Baumeister, T.]]
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[[Category: Baumeister T]]
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[[Category: Brien, T O.]]
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[[Category: Buckmelter AJ]]
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[[Category: Buckmelter, A J.]]
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[[Category: Caligiuri M]]
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[[Category: Caligiuri, M.]]
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[[Category: Clodfelter KH]]
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[[Category: Clodfelter, K H.]]
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[[Category: Dragovich PS]]
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[[Category: Dragovich, P S.]]
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[[Category: Gunzner-Tosteb J]]
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[[Category: Gunzner-Tosteb, J.]]
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[[Category: Han B]]
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[[Category: Han, B.]]
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[[Category: Ho Y]]
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[[Category: Ho, Y.]]
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[[Category: Kley N]]
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[[Category: Kley, N.]]
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[[Category: Liederer BM]]
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[[Category: Liederer, B M.]]
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[[Category: Lin J]]
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[[Category: Lin, J.]]
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[[Category: Ly J]]
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[[Category: Ly, J.]]
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[[Category: O'Brien T]]
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[[Category: Oh, A.]]
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[[Category: Oh A]]
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[[Category: Reynolds, D J.]]
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[[Category: Reynolds DJ]]
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[[Category: Sharma, G.]]
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[[Category: Sharma G]]
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[[Category: Smith, C C.]]
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[[Category: Smith CC]]
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[[Category: Wang, L.]]
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[[Category: Wang L]]
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[[Category: Wang, W.]]
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[[Category: Wang W]]
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[[Category: Wang, Z.]]
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[[Category: Wang Z]]
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[[Category: Xiao, Y.]]
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[[Category: Xiao Y]]
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[[Category: Yuen, P.]]
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[[Category: Yuen P]]
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[[Category: Zak, M.]]
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[[Category: Zak M]]
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[[Category: Zhao, G.]]
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[[Category: Zhao G]]
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[[Category: Zheng, X.]]
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[[Category: Zheng X]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

PDB ID 4kfo

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