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4jri

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'''Unreleased structure'''
 
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The entry 4jri is ON HOLD until Paper Publication
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==Crystal Structure of Escherichia coli Hfq Proximal Edge Mutant==
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<StructureSection load='4jri' size='340' side='right'caption='[[4jri]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4jri]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JRI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JRI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.829&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jri OCA], [https://pdbe.org/4jri PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jri RCSB], [https://www.ebi.ac.uk/pdbsum/4jri PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jri ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HFQ_ECOLI HFQ_ECOLI] RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32. Binds with high specificity to tRNAs. In vitro, stimulates synthesis of long tails by poly(A) polymerase I. Required for RNA phage Qbeta replication.<ref>PMID:805130</ref> <ref>PMID:10677490</ref> <ref>PMID:11222598</ref> <ref>PMID:17158661</ref> <ref>PMID:19909729</ref> Seems to play a role in persister cell formation; upon overexpression decreases persister cell formation while deletion increases persister formation.<ref>PMID:805130</ref> <ref>PMID:10677490</ref> <ref>PMID:11222598</ref> <ref>PMID:17158661</ref> <ref>PMID:19909729</ref>
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Authors: Robinson, K.E., Orans, J.
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==See Also==
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*[[Protein Hfq 3D structures|Protein Hfq 3D structures]]
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Description: Crystal Structure of Escherichia coli Hfq Proximal Edge Mutant
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli K-12]]
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[[Category: Large Structures]]
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[[Category: Orans J]]
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[[Category: Robinson KE]]

Current revision

Crystal Structure of Escherichia coli Hfq Proximal Edge Mutant

PDB ID 4jri

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