4l98

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(New page: '''Unreleased structure''' The entry 4l98 is ON HOLD until Paper Publication Authors: Pochetti, G., Montanari, R., Consalvi, V., Chiaraluce, R., Pasquo, A., Capelli, C., Loiodice, F., L...)
Current revision (16:02, 14 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4l98 is ON HOLD until Paper Publication
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==Crystal structure of the complex of F360L PPARgamma mutant with the ligand LT175==
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<StructureSection load='4l98' size='340' side='right'caption='[[4l98]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4l98]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L98 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LRG:(2S)-2-(BIPHENYL-4-YLOXY)-3-PHENYLPROPANOIC+ACID'>LRG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l98 OCA], [https://pdbe.org/4l98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l98 RCSB], [https://www.ebi.ac.uk/pdbsum/4l98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l98 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9753710</ref> Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:[https://omim.org/entry/604367 604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.<ref>PMID:12453919</ref> <ref>PMID:11788685</ref> Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
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== Function ==
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[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>
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Authors: Pochetti, G., Montanari, R., Consalvi, V., Chiaraluce, R., Pasquo, A., Capelli, C., Loiodice, F., Laghezza, A., Lori, C.
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==See Also==
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*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
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Description: Crystal structure of the complex of F360L PPARgamma mutant with the ligand LT175
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Capelli C]]
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[[Category: Chiaraluce R]]
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[[Category: Consalvi V]]
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[[Category: Laghezza A]]
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[[Category: Loiodice F]]
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[[Category: Lori C]]
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[[Category: Montanari R]]
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[[Category: Pasquo A]]
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[[Category: Pochetti G]]

Current revision

Crystal structure of the complex of F360L PPARgamma mutant with the ligand LT175

PDB ID 4l98

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