This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4l9u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 4l9u is ON HOLD Authors: Iwig, J.S., Vercoulen, Y., Das, R., Barros, T., Limnander, A., Che, Y., Pelton, J.G., Wemmer, D.E., Roose, J.P., Kuriyan, J...)
Current revision (12:18, 1 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 4l9u is ON HOLD
+
==Structure of C-terminal coiled coil of RasGRP1==
-
 
+
<StructureSection load='4l9u' size='340' side='right'caption='[[4l9u]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
Authors: Iwig, J.S., Vercoulen, Y., Das, R., Barros, T., Limnander, A., Che, Y., Pelton, J.G., Wemmer, D.E., Roose, J.P., Kuriyan, J.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4l9u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L9U FirstGlance]. <br>
-
Description: Structure of C-terminal coiled coil of RasGRP1
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6014&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l9u OCA], [https://pdbe.org/4l9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l9u RCSB], [https://www.ebi.ac.uk/pdbsum/4l9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l9u ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/GRP1_HUMAN GRP1_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry. Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GRP1_HUMAN GRP1_HUMAN] Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating allergic responses. May also function in other cell types differentiation.<ref>PMID:10807788</ref> <ref>PMID:12839994</ref> <ref>PMID:12782630</ref> <ref>PMID:12845332</ref> <ref>PMID:15060167</ref> <ref>PMID:15184873</ref> <ref>PMID:15899849</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Barros T]]
 +
[[Category: Che Y]]
 +
[[Category: Das R]]
 +
[[Category: Iwig JS]]
 +
[[Category: Kuriyan J]]
 +
[[Category: Limnander A]]
 +
[[Category: Pelton JG]]
 +
[[Category: Roose JP]]
 +
[[Category: Vercoulen Y]]
 +
[[Category: Wemmer DE]]

Current revision

Structure of C-terminal coiled coil of RasGRP1

PDB ID 4l9u

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4l9u"
Personal tools