2hxb
From Proteopedia
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| - | [[Image:2hxb.jpg|left|200px]]<br /><applet load="2hxb" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2hxb, resolution 2.550Å" /> | ||
| - | '''dCTP deaminase-dUTPase from Methanocaldococcus jannaschii'''<br /> | ||
| - | == | + | ==dCTP deaminase-dUTPase from Methanocaldococcus jannaschii== |
| - | + | <StructureSection load='2hxb' size='340' side='right'caption='[[2hxb]], [[Resolution|resolution]] 2.55Å' scene=''> | |
| - | [[ | + | == Structural highlights == |
| - | [ | + | <table><tr><td colspan='2'>[[2hxb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HXB FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55Å</td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hxb OCA], [https://pdbe.org/2hxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hxb RCSB], [https://www.ebi.ac.uk/pdbsum/2hxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hxb ProSAT]</span></td></tr> |
| - | [ | + | </table> |
| - | [[ | + | == Function == |
| - | [ | + | [https://www.uniprot.org/uniprot/DCDB_METJA DCDB_METJA] Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase with a lower affinity for dUTP than for dCTP.<ref>PMID:12538648</ref> <ref>PMID:12670946</ref> |
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hx/2hxb_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hxb ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Deaminase 3D structures|Deaminase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Methanocaldococcus jannaschii]] | ||
| + | [[Category: Bynck JH]] | ||
| + | [[Category: Johansson E]] | ||
Current revision
dCTP deaminase-dUTPase from Methanocaldococcus jannaschii
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