4jbj

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{{STRUCTURE_4jbj| PDB=4jbj | SCENE= }}
 
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===Structural mimicry for functional antagonism===
 
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==Function==
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==Structural mimicry for functional antagonism==
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[[http://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE]] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref>
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<StructureSection load='4jbj' size='340' side='right'caption='[[4jbj]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4jbj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JBJ FirstGlance]. <br>
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[[4jbj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBJ OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.692&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbj OCA], [https://pdbe.org/4jbj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jbj RCSB], [https://www.ebi.ac.uk/pdbsum/4jbj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jbj ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:023567559</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Cheng, G.]]
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[[Category: Cheng G]]
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[[Category: Ding, W.]]
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[[Category: Ding W]]
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[[Category: Hung, L W.]]
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[[Category: Hung L-W]]
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[[Category: Liu, Z J.]]
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[[Category: Liu Z-J]]
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[[Category: Ma, F.]]
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[[Category: Ma F]]
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[[Category: Ni, X.]]
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[[Category: Ni X]]
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[[Category: Ru, H.]]
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[[Category: Ru H]]
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[[Category: Shaw, N.]]
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[[Category: Shaw N]]
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[[Category: Zhao, L.]]
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[[Category: Zhao L]]
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[[Category: Dna binding protein]]
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[[Category: Ds dna]]
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[[Category: Ob fold]]
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Structural mimicry for functional antagonism

PDB ID 4jbj

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