4g2y

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{{STRUCTURE_4g2y| PDB=4g2y | SCENE= }}
 
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===Crystal structure of PDE5A complexed with its inhibitor===
 
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{{ABSTRACT_PUBMED_23137303}}
 
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==Function==
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==Crystal structure of PDE5A complexed with its inhibitor==
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[[http://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
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<StructureSection load='4g2y' size='340' side='right'caption='[[4g2y]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4g2y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G2Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI5:2-{5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]-2-PROPOXYPHENYL}-3,5,6,7-TETRAHYDRO-4H-CYCLOPENTA[D]PYRIMIDIN-4-ONE'>NI5</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2y OCA], [https://pdbe.org/4g2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g2y RCSB], [https://www.ebi.ac.uk/pdbsum/4g2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
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==About this Structure==
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==See Also==
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[[4g2y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2Y OCA].
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:023137303</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, T T.]]
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[[Category: Large Structures]]
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[[Category: Ren, J.]]
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[[Category: Chen TT]]
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[[Category: Xu, Y C.]]
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[[Category: Ren J]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Xu YC]]
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[[Category: Phosphodiesterase]]
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Current revision

Crystal structure of PDE5A complexed with its inhibitor

PDB ID 4g2y

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