3w1f

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{{STRUCTURE_3w1f| PDB=3w1f | SCENE= }}
 
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===Crystal structure of Human MPS1 catalytic domain in complex with 5-(5-ethoxy-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl)-2-methylbenzenesulfonamide===
 
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{{ABSTRACT_PUBMED_23634759}}
 
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==Function==
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==Crystal structure of Human MPS1 catalytic domain in complex with 5-(5-ethoxy-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl)-2-methylbenzenesulfonamide==
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[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
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<StructureSection load='3w1f' size='340' side='right'caption='[[3w1f]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3w1f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W1F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1O5:5-[5-ETHOXY-6-(1-METHYL-1H-PYRAZOL-4-YL)-1H-INDAZOL-3-YL]-2-METHYLBENZENESULFONAMIDE'>1O5</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w1f OCA], [https://pdbe.org/3w1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w1f RCSB], [https://www.ebi.ac.uk/pdbsum/3w1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w1f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
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==About this Structure==
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==See Also==
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[[3w1f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W1F OCA].
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*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023634759</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Dual-specificity kinase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Baba, Y.]]
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[[Category: Large Structures]]
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[[Category: Daigo, Y.]]
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[[Category: Baba Y]]
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[[Category: Dohi, K.]]
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[[Category: Daigo Y]]
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[[Category: Hashizume, H.]]
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[[Category: Dohi K]]
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[[Category: Hato, Y.]]
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[[Category: Hashizume H]]
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[[Category: Higaki, M.]]
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[[Category: Hato Y]]
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[[Category: Higashino, K.]]
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[[Category: Higaki M]]
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[[Category: Ide, N.]]
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[[Category: Higashino K]]
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[[Category: Iguchi, M.]]
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[[Category: Ide N]]
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[[Category: Inoue, M.]]
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[[Category: Iguchi M]]
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[[Category: Ishioka, Y.]]
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[[Category: Inoue M]]
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[[Category: Itoh, T.]]
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[[Category: Ishioka Y]]
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[[Category: Kanazawa, T.]]
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[[Category: Itoh T]]
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[[Category: Kido, Y.]]
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[[Category: Kanazawa T]]
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[[Category: Kusakabe, K.]]
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[[Category: Kido Y]]
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[[Category: Maeda, M.]]
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[[Category: Kusakabe K]]
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[[Category: Murai, H.]]
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[[Category: Maeda M]]
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[[Category: Nakamura, Y.]]
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[[Category: Murai H]]
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[[Category: Okano, Y.]]
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[[Category: Nakamura Y]]
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[[Category: Sakamoto, S.]]
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[[Category: Okano Y]]
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[[Category: Sato, Y.]]
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[[Category: Sakamoto S]]
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[[Category: Shiota, T.]]
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[[Category: Sato Y]]
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[[Category: Tachibana, Y.]]
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[[Category: Shiota T]]
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[[Category: Ueda, K.]]
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[[Category: Tachibana Y]]
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[[Category: Yamamoto, T.]]
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[[Category: Ueda K]]
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[[Category: Yasuo, K.]]
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[[Category: Yamamoto T]]
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[[Category: Yoshizawa, H.]]
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[[Category: Yasuo K]]
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[[Category: Kinase]]
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[[Category: Yoshizawa H]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal structure of Human MPS1 catalytic domain in complex with 5-(5-ethoxy-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl)-2-methylbenzenesulfonamide

PDB ID 3w1f

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