2m9e

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{{STRUCTURE_2m9e| PDB=2m9e | SCENE= }}
 
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===NMR solution structure of Pin1 WW domain mutant 5-1===
 
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==Function==
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==NMR solution structure of Pin1 WW domain mutant 5-1==
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[[http://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
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<StructureSection load='2m9e' size='340' side='right'caption='[[2m9e]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2m9e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M9E FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9e OCA], [https://pdbe.org/2m9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m9e RCSB], [https://www.ebi.ac.uk/pdbsum/2m9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m9e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Carbohydrate-aromatic interactions mediate many biological processes. However, the structure-energy relationships underpinning direct carbohydrate-aromatic packing in aqueous solution have been difficult to assess experimentally and remain elusive. Here, we determine the structures and folding energetics of chemically synthesized glycoproteins to quantify the contributions of the hydrophobic effect and CH-pi interactions to carbohydrate-aromatic packing interactions in proteins. We find that the hydrophobic effect contributes significantly to protein-carbohydrate interactions. Interactions between carbohydrates and aromatic amino acid side chains, however, are supplemented by CH-pi interactions. The strengths of experimentally determined carbohydrate-pi interactions do not correlate with the electrostatic properties of the involved aromatic residues, suggesting that the electrostatic component of CH-pi interactions in aqueous solution is small. Thus, tight binding of carbohydrates and aromatic residues is driven by the hydrophobic effect and CH-pi interactions featuring a dominating dispersive component.
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==About this Structure==
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The Structural and Energetic Basis of Carbohydrate-Aromatic Packing Interactions in Proteins.,Chen W, Enck S, Price JL, Powers DL, Powers ET, Wong CH, Dyson HJ, Kelly JW J Am Chem Soc. 2013 Jun 7. PMID:23742246<ref>PMID:23742246</ref>
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[[2m9e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9E OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<references group="xtra"/><references/>
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</div>
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[[Category: Chen, W.]]
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<div class="pdbe-citations 2m9e" style="background-color:#fffaf0;"></div>
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[[Category: Dyson, H J.]]
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[[Category: Enck, S.]]
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==See Also==
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[[Category: Kelly, J W.]]
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*[[Peptidyl-prolyl cis-trans isomerase 3D structures|Peptidyl-prolyl cis-trans isomerase 3D structures]]
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[[Category: Powers, E T.]]
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== References ==
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[[Category: Price, J L.]]
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<references/>
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[[Category: Wong, C.]]
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__TOC__
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[[Category: Ch-pi interaction]]
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</StructureSection>
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[[Category: Enhanced aromatic sequon]]
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[[Category: Homo sapiens]]
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[[Category: Isomerase]]
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[[Category: Large Structures]]
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[[Category: N-glycosylation]]
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[[Category: Chen W]]
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[[Category: Ww domain]]
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[[Category: Dyson HJ]]
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[[Category: Enck S]]
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[[Category: Kelly JW]]
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[[Category: Powers ET]]
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[[Category: Price JL]]
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[[Category: Wong C]]

Current revision

NMR solution structure of Pin1 WW domain mutant 5-1

PDB ID 2m9e

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