4ifp

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{{STRUCTURE_4ifp| PDB=4ifp | SCENE= }}
 
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===X-ray Crystal Structure of Human NLRP1 CARD Domain===
 
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{{ABSTRACT_PUBMED_23508996}}
 
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==Function==
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==X-ray Crystal Structure of Human NLRP1 CARD Domain==
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[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
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<StructureSection load='4ifp' size='340' side='right'caption='[[4ifp]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ifp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IFP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9948&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ifp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ifp OCA], [https://pdbe.org/4ifp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ifp RCSB], [https://www.ebi.ac.uk/pdbsum/4ifp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ifp ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NLRP1_HUMAN NLRP1_HUMAN] Vitiligo-associated autoimmune disease;Vitiligo;Corneal intraepithelial dyskeratosis with palmoplantar hyperkeratosis and laryngeal dyskeratosis. Disease susceptibility is associated with variations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease may be caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/NLRP1_HUMAN NLRP1_HUMAN] As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin (PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). Binds ATP (PubMed:11113115, PubMed:15212762).[UniProtKB:A1Z198]<ref>PMID:11113115</ref> <ref>PMID:15212762</ref> <ref>PMID:17349957</ref> <ref>PMID:17418785</ref> <ref>PMID:18511561</ref> <ref>PMID:19651869</ref> <ref>PMID:22665479</ref> <ref>PMID:27662089</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The NLRP1 inflammasome responds to microbial challenges such as Bacillus anthracis infection and is implicated in autoimmune disease such as vitiligo. Human NLRP1 contains both an N-terminal pyrin domain (PYD) and a C-terminal caspase recruitment domain (CARD), with the latter being essential for its association with the downstream effector procaspase-1. Here we report a 2.0 A crystal structure of the human NLRP1 CARD as a fusion with the maltose-binding protein. The structure reveals the six-helix bundle fold of the NLRP1 CARD, typical of the death domain superfamily. The charge surface of the NLRP1 CARD structure and a procaspase-1 CARD model suggests potential mechanisms for their association through electrostatic attraction. Proteins 2013. (c) 2013 Wiley Periodicals, Inc.
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==About this Structure==
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Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1.,Jin T, Curry J, Smith P, Jiang J, Xiao TS Proteins. 2013 Mar 18. doi: 10.1002/prot.24287. PMID:23508996<ref>PMID:23508996</ref>
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[[4ifp]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IFP OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023508996</ref><references group="xtra"/><references/>
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</div>
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[[Category: Curry, J.]]
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<div class="pdbe-citations 4ifp" style="background-color:#fffaf0;"></div>
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[[Category: Jiang, J.]]
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[[Category: Jin, T.]]
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==See Also==
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[[Category: Smith, P.]]
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*[[Pyrin domain|Pyrin domain]]
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[[Category: Xiao, T.]]
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== References ==
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[[Category: Death fold superfamily]]
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<references/>
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[[Category: Immune system]]
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__TOC__
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[[Category: Inflammasome]]
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</StructureSection>
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[[Category: Innate immune system]]
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[[Category: Escherichia coli K-12]]
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[[Category: Signal transduction]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Curry J]]
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[[Category: Jiang J]]
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[[Category: Jin T]]
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[[Category: Smith P]]
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[[Category: Xiao T]]

Current revision

X-ray Crystal Structure of Human NLRP1 CARD Domain

PDB ID 4ifp

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