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2i1o

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[[Image:2i1o.gif|left|200px]]<br /><applet load="2i1o" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2i1o, resolution 2.40&Aring;" />
 
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'''Crystal Structure of a Nicotinate Phosphoribosyltransferase from Thermoplasma acidophilum'''<br />
 
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==About this Structure==
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==Crystal Structure of a Nicotinate Phosphoribosyltransferase from Thermoplasma acidophilum==
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2I1O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=TRS:'>TRS</scene>, <scene name='pdbligand=MPD:'>MPD</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1O OCA].
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<StructureSection load='2i1o' size='340' side='right'caption='[[2i1o]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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[[Category: Single protein]]
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== Structural highlights ==
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[[Category: Thermoplasma acidophilum]]
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<table><tr><td colspan='2'>[[2i1o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I1O FirstGlance]. <br>
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[[Category: BSGC, Berkeley Structural Genomics Center.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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[[Category: Kim, R.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Kim, S H.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1o OCA], [https://pdbe.org/2i1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i1o RCSB], [https://www.ebi.ac.uk/pdbsum/2i1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1o ProSAT], [https://www.topsan.org/Proteins/BSGC/2i1o TOPSAN]</span></td></tr>
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[[Category: Shin, D H.]]
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</table>
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[[Category: ACY]]
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== Function ==
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[[Category: MPD]]
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[https://www.uniprot.org/uniprot/PNCB_THEAC PNCB_THEAC] Catalyzes the transfer of the phosphoribosyl moiety of phosphoribosylpyrophosphate (PRPP) onto nicotinate (NA) to yield nicotinate mononucleotide (NAMN), an intermediate in the biosynthesis of NAD. Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
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[[Category: PO4]]
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== Evolutionary Conservation ==
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[[Category: TRS]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: ZN]]
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Check<jmol>
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[[Category: berkeley structural genomics center]]
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<jmolCheckbox>
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[[Category: bsgc]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/2i1o_consurf.spt"</scriptWhenChecked>
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[[Category: crystal structure]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: nicotinate phosphoribosyltransferase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: protein structure initiative]]
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</jmolCheckbox>
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[[Category: psi]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i1o ConSurf].
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[[Category: structural genomics]]
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<div style="clear:both"></div>
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[[Category: zin ion]]
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[[Category: zinc finger motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:48:09 2008''
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==See Also==
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Thermoplasma acidophilum]]
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[[Category: Kim R]]
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[[Category: Kim S-H]]
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[[Category: Shin DH]]

Current revision

Crystal Structure of a Nicotinate Phosphoribosyltransferase from Thermoplasma acidophilum

PDB ID 2i1o

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