2i1y

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[[Image:2i1y.gif|left|200px]]<br /><applet load="2i1y" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2i1y, resolution 2.23&Aring;" />
 
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'''Crystal structure of the phosphatase domain of human PTP IA-2'''<br />
 
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==About this Structure==
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==Crystal structure of the phosphatase domain of human PTP IA-2==
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2I1Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1Y OCA].
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<StructureSection load='2i1y' size='340' side='right'caption='[[2i1y]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Protein-tyrosine-phosphatase]]
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<table><tr><td colspan='2'>[[2i1y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I1Y FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
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[[Category: Almo, S C.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[Category: Alvarado, J.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1y OCA], [https://pdbe.org/2i1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i1y RCSB], [https://www.ebi.ac.uk/pdbsum/2i1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1y ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2i1y TOPSAN]</span></td></tr>
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[[Category: Atwell, S.]]
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</table>
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[[Category: Bain, K T.]]
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== Function ==
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[[Category: Burley, S K.]]
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[https://www.uniprot.org/uniprot/PTPRN_HUMAN PTPRN_HUMAN] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.<ref>PMID:8144912</ref> <ref>PMID:8641276</ref>
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[[Category: Faber-Barata, J.]]
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== Evolutionary Conservation ==
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[[Category: Freeman, M.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Kearins, M C.]]
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Check<jmol>
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[[Category: Koss, J.]]
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<jmolCheckbox>
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[[Category: Maletic, M.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/2i1y_consurf.spt"</scriptWhenChecked>
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Ozyurt, S.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Patskovsky, Y.]]
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</jmolCheckbox>
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[[Category: Powell, A.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i1y ConSurf].
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[[Category: Rooney, I.]]
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<div style="clear:both"></div>
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[[Category: Russell, J C.]]
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<div style="background-color:#fffaf0;">
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[[Category: Smith, D.]]
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== Publication Abstract from PubMed ==
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[[Category: Thompson, D A.]]
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The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.
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[[Category: Wasserman, S R.]]
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[[Category: GOL]]
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[[Category: new york structural genomix research consortium]]
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[[Category: nysgxrc]]
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[[Category: phosphatase]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: receptor-type protein tyrosine phosphatase precursor]]
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[[Category: structural genomics]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:48:13 2008''
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Structural genomics of protein phosphatases.,Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:18058037<ref>PMID:18058037</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2i1y" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Almo SC]]
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[[Category: Alvarado J]]
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[[Category: Atwell S]]
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[[Category: Bain KT]]
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[[Category: Burley SK]]
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[[Category: Faber-Barata J]]
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[[Category: Freeman M]]
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[[Category: Kearins MC]]
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[[Category: Koss J]]
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[[Category: Maletic M]]
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[[Category: Ozyurt S]]
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[[Category: Patskovsky Y]]
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[[Category: Powell A]]
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[[Category: Rooney I]]
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[[Category: Russell JC]]
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[[Category: Smith D]]
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[[Category: Thompson DA]]
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[[Category: Wasserman SR]]

Current revision

Crystal structure of the phosphatase domain of human PTP IA-2

PDB ID 2i1y

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