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3s9a
From Proteopedia
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| - | {{STRUCTURE_3s9a| PDB=3s9a | SCENE= }} | ||
| - | ===Russell's viper venom serine proteinase, RVV-V (closed-form)=== | ||
| - | {{ABSTRACT_PUBMED_21871889}} | ||
| - | == | + | ==Russell's viper venom serine proteinase, RVV-V (closed-form)== |
| - | [[http://www.uniprot.org/uniprot/VSPG_DABSI VSPG_DABSI | + | <StructureSection load='3s9a' size='340' side='right'caption='[[3s9a]], [[Resolution|resolution]] 1.90Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3s9a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_siamensis Daboia siamensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S9A FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s9a OCA], [https://pdbe.org/3s9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s9a RCSB], [https://www.ebi.ac.uk/pdbsum/3s9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s9a ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VSPG_DABSI VSPG_DABSI] Venom serine protease that selectively activates factor V (F5) in a calcium-independent manner. It cleaves the Arg(1545)-Ser(1546) linkage in the human factor V molecule. Induces the coagulation of mammalian plasma.<ref>PMID:3053712</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Russell's viper venom factor V (FV) activator (RVV-V) is a thrombin-like proteinase that specifically cleaves the Arg1545-Ser1546 bond of FV. Here we present the crystal structure of RVV-V in complex with the FV14 peptide (residues 1533-1546 of human FV) determined at 1.8A resolution. The structure reveals multiple interactions between RVV-V and the seven residues, Ile1539 (P(7))-Arg1545 (P(1)), of the cleaved substrate. Comparison with substrate-free structures reveals conformational changes of the RVV-V loops upon substrate binding, suggesting that the multiple interactions are mediated by an induced-fit mechanism. The results provide an explanation for the narrow specificity of RVV-V. | ||
| - | + | Structural basis of coagulation factor V recognition for cleavage by RVV-V.,Nakayama D, Ben Ammar Y, Miyata T, Takeda S FEBS Lett. 2011 Aug 23. PMID:21871889<ref>PMID:21871889</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | < | + | </div> |
| - | [[Category: Daboia | + | <div class="pdbe-citations 3s9a" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | |
| - | [[Category: Ammar | + | ==See Also== |
| - | [[Category: Nakayama | + | *[[Proteinase 3D structures|Proteinase 3D structures]] |
| - | [[Category: Takeda | + | == References == |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Daboia siamensis]] | |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ben Ammar Y]] | ||
| + | [[Category: Nakayama D]] | ||
| + | [[Category: Takeda S]] | ||
Current revision
Russell's viper venom serine proteinase, RVV-V (closed-form)
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