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| - | {{STRUCTURE_4k6j| PDB=4k6j | SCENE= }} | |
| - | ===Human cohesin inhibitor WapL=== | |
| - | {{ABSTRACT_PUBMED_23776203}} | |
| | | | |
| - | ==Function== | + | ==Human cohesin inhibitor WapL== |
| - | [[http://www.uniprot.org/uniprot/WAPL_HUMAN WAPL_HUMAN]] Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.<ref>PMID:15150110</ref> <ref>PMID:17113138</ref> <ref>PMID:17112726</ref> <ref>PMID:19696148</ref> <ref>PMID:19907496</ref> <ref>PMID:21111234</ref> | + | <StructureSection load='4k6j' size='340' side='right'caption='[[4k6j]], [[Resolution|resolution]] 2.62Å' scene=''> |
| - | | + | == Structural highlights == |
| - | ==About this Structure== | + | <table><tr><td colspan='2'>[[4k6j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K6J FirstGlance]. <br> |
| - | [[4k6j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6J OCA].
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6205Å</td></tr> |
| - | | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | ==Reference==
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k6j OCA], [https://pdbe.org/4k6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k6j RCSB], [https://www.ebi.ac.uk/pdbsum/4k6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k6j ProSAT]</span></td></tr> |
| - | <ref group="xtra">PMID:023776203</ref><references group="xtra"/><references/>
| + | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/WAPL_HUMAN WAPL_HUMAN] Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.<ref>PMID:15150110</ref> <ref>PMID:17113138</ref> <ref>PMID:17112726</ref> <ref>PMID:19696148</ref> <ref>PMID:19907496</ref> <ref>PMID:21111234</ref> |
| | + | == References == |
| | + | <references/> |
| | + | __TOC__ |
| | + | </StructureSection> |
| | [[Category: Homo sapiens]] | | [[Category: Homo sapiens]] |
| - | [[Category: Ouyang, Z.]] | + | [[Category: Large Structures]] |
| - | [[Category: Tomchick, D R.]] | + | [[Category: Ouyang Z]] |
| - | [[Category: Yu, H.]] | + | [[Category: Tomchick DR]] |
| - | [[Category: Cell adhesion inhibitor]] | + | [[Category: Yu H]] |
| - | [[Category: Cell cycle]]
| + | |
| - | [[Category: Cohesin regulator]]
| + | |
| - | [[Category: Heat repeat]]
| + | |
| - | [[Category: Nuclear protein]]
| + | |
| - | [[Category: Protein-binding]]
| + | |
| Structural highlights
Function
WAPL_HUMAN Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.[1] [2] [3] [4] [5] [6]
References
- ↑ Oikawa K, Ohbayashi T, Kiyono T, Nishi H, Isaka K, Umezawa A, Kuroda M, Mukai K. Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression. Cancer Res. 2004 May 15;64(10):3545-9. PMID:15150110 doi:10.1158/0008-5472.CAN-03-3822
- ↑ Kueng S, Hegemann B, Peters BH, Lipp JJ, Schleiffer A, Mechtler K, Peters JM. Wapl controls the dynamic association of cohesin with chromatin. Cell. 2006 Dec 1;127(5):955-67. Epub 2006 Nov 16. PMID:17113138 doi:10.1016/j.cell.2006.09.040
- ↑ Gandhi R, Gillespie PJ, Hirano T. Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. Curr Biol. 2006 Dec 19;16(24):2406-17. Epub 2006 Nov 16. PMID:17112726 doi:10.1016/j.cub.2006.10.061
- ↑ Shintomi K, Hirano T. Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1. Genes Dev. 2009 Sep 15;23(18):2224-36. doi: 10.1101/gad.1844309. Epub 2009 Aug, 20. PMID:19696148 doi:10.1101/gad.1844309
- ↑ Terret ME, Sherwood R, Rahman S, Qin J, Jallepalli PV. Cohesin acetylation speeds the replication fork. Nature. 2009 Nov 12;462(7270):231-4. PMID:19907496 doi:nature08550
- ↑ Nishiyama T, Ladurner R, Schmitz J, Kreidl E, Schleiffer A, Bhaskara V, Bando M, Shirahige K, Hyman AA, Mechtler K, Peters JM. Sororin mediates sister chromatid cohesion by antagonizing Wapl. Cell. 2010 Nov 24;143(5):737-49. doi: 10.1016/j.cell.2010.10.031. PMID:21111234 doi:10.1016/j.cell.2010.10.031
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