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4is8

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{{STRUCTURE_4is8| PDB=4is8 | SCENE= }}
 
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===Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors===
 
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{{ABSTRACT_PUBMED_23737522}}
 
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==Function==
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==Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors==
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[[http://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN]] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
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<StructureSection load='4is8' size='340' side='right'caption='[[4is8]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4is8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IS8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.78&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4is8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4is8 OCA], [https://pdbe.org/4is8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4is8 RCSB], [https://www.ebi.ac.uk/pdbsum/4is8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4is8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
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==About this Structure==
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==See Also==
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[[4is8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IS8 OCA].
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*[[Liver receptor homolog-1|Liver receptor homolog-1]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:023737522</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Musille, P M.]]
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[[Category: Large Structures]]
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[[Category: Ortlund, E A.]]
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[[Category: Musille PM]]
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[[Category: Pathak, M C.]]
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[[Category: Ortlund EA]]
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[[Category: Ligand binding domain]]
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[[Category: Pathak MC]]
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[[Category: Transcription]]
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Current revision

Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors

PDB ID 4is8

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