This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.


Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2i2o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:26, 24 March 2021) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2i2o.gif|left|200px]]<br /><applet load="2i2o" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2i2o, resolution 1.920&Aring;" />
 
-
'''Crystal Structure of an eIF4G-like Protein from Danio rerio'''<br />
 
-
==About this Structure==
+
==Crystal Structure of an eIF4G-like Protein from Danio rerio==
-
2I2O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio] with <scene name='pdbligand=NI:'>NI</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2O OCA].
+
<StructureSection load='2i2o' size='340' side='right'caption='[[2i2o]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
-
[[Category: Danio rerio]]
+
== Structural highlights ==
-
[[Category: Single protein]]
+
<table><tr><td colspan='2'>[[2i2o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I2O FirstGlance]. <br>
-
[[Category: Bingman, C A.]]
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-
[[Category: Bitto, E.]]
+
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dr.38751 (BC090306) ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
-
[[Category: Jr., G N.Phillips.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i2o OCA], [https://pdbe.org/2i2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i2o RCSB], [https://www.ebi.ac.uk/pdbsum/2i2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i2o ProSAT], [https://www.topsan.org/Proteins/CESG/2i2o TOPSAN]</span></td></tr>
-
[[Category: Mccoy, J G.]]
+
</table>
-
[[Category: Wesenberg, G E.]]
+
== Function ==
-
[[Category: NI]]
+
[[https://www.uniprot.org/uniprot/M4GDB_DANRE M4GDB_DANRE]] Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (By similarity).
-
[[Category: center for eukaryotic structural genomics]]
+
== Evolutionary Conservation ==
-
[[Category: cesg]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: eif4g-like protein]]
+
Check<jmol>
-
[[Category: protein structure initiative]]
+
<jmolCheckbox>
-
[[Category: psi]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i2/2i2o_consurf.spt"</scriptWhenChecked>
-
 
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:48:25 2008''
+
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i2o ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Brachidanio rerio]]
 +
[[Category: Large Structures]]
 +
[[Category: Bingman, C A]]
 +
[[Category: Bitto, E]]
 +
[[Category: Structural genomic]]
 +
[[Category: Mccoy, J G]]
 +
[[Category: Phillips, G N]]
 +
[[Category: Wesenberg, G E]]
 +
[[Category: Cesg]]
 +
[[Category: Eif4g-like protein]]
 +
[[Category: PSI, Protein structure initiative]]
 +
[[Category: Unknown function]]

Current revision

Crystal Structure of an eIF4G-like Protein from Danio rerio

PDB ID 2i2o

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools