4ef5

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{{STRUCTURE_4ef5| PDB=4ef5 | SCENE= }}
 
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===Crystal structure of STING CTD===
 
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{{ABSTRACT_PUBMED_22579474}}
 
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==Function==
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==Crystal structure of STING CTD==
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[[http://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>
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<StructureSection load='4ef5' size='340' side='right'caption='[[4ef5]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ef5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EF5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ef5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ef5 OCA], [https://pdbe.org/4ef5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ef5 RCSB], [https://www.ebi.ac.uk/pdbsum/4ef5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ef5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>
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==About this Structure==
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==See Also==
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[[4ef5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF5 OCA].
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*[[Stimulator of interferon genes protein|Stimulator of interferon genes protein]]
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*[[Stimulator of interferon genes protein 3D structures|Stimulator of interferon genes protein 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:022579474</ref><references group="xtra"/><references/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Jiang, Y.]]
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[[Category: Large Structures]]
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[[Category: Li, Y.]]
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[[Category: Jiang Y]]
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[[Category: Liu, Z J.]]
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[[Category: Li Y]]
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[[Category: Niu, F.]]
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[[Category: Liu Z-J]]
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[[Category: Ouyang, S.]]
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[[Category: Niu F]]
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[[Category: Qiu, W.]]
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[[Category: Ouyang S]]
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[[Category: Ru, H.]]
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[[Category: Qiu W]]
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[[Category: Shaw, N.]]
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[[Category: Ru H]]
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[[Category: Zhu, Y.]]
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[[Category: Shaw N]]
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[[Category: 5 helices and 5 strands in single domain]]
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[[Category: Zhu Y]]
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[[Category: C-di-gmp]]
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[[Category: Dimerization]]
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[[Category: Immune system]]
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[[Category: Innate immune system]]
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[[Category: Sting/mita/eris/mpys/tmem173]]
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[[Category: Type i interferon]]
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Current revision

Crystal structure of STING CTD

PDB ID 4ef5

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