4i03
From Proteopedia
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| - | {{STRUCTURE_4i03| PDB=4i03 | SCENE= }} | ||
| - | ===Human MMP12 in complex with a PEG-linked bifunctional L-glutamate motif inhibitor=== | ||
| - | {{ABSTRACT_PUBMED_23567804}} | ||
| - | == | + | ==Human MMP12 in complex with a PEG-linked bifunctional L-glutamate motif inhibitor== |
| - | [[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN | + | <StructureSection load='4i03' size='340' side='right'caption='[[4i03]], [[Resolution|resolution]] 1.70Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4i03]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I03 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L88:(4R,22R)-5,21-DIOXO-4,22-BIS({3-[4-(4-PHENYLTHIOPHEN-2-YL)PHENYL]PROPANOYL}AMINO)-10,13,16-TRIOXA-6,20-DIAZAPENTACOSANE-1,25-DIOIC+ACID'>L88</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i03 OCA], [https://pdbe.org/4i03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i03 RCSB], [https://www.ebi.ac.uk/pdbsum/4i03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i03 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Cassar-Lajeunesse | + | [[Category: Cassar-Lajeunesse E]] |
| - | [[Category: Devel | + | [[Category: Devel L]] |
| - | [[Category: Dive | + | [[Category: Dive V]] |
| - | [[Category: Stura | + | [[Category: Stura EA]] |
| - | [[Category: Vera | + | [[Category: Vera L]] |
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Current revision
Human MMP12 in complex with a PEG-linked bifunctional L-glutamate motif inhibitor
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