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3s5a

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{{STRUCTURE_3s5a| PDB=3s5a | SCENE= }}
 
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===ABH2 cross-linked to undamaged dsDNA-2 with cofactors===
 
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{{ABSTRACT_PUBMED_22659876}}
 
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==Function==
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==ABH2 cross-linked to undamaged dsDNA-2 with cofactors==
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[[http://www.uniprot.org/uniprot/ALKB2_HUMAN ALKB2_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.<ref>PMID:12486230</ref> <ref>PMID:12594517</ref> <ref>PMID:16174769</ref> <ref>PMID:18519673</ref> <ref>PMID:18432238</ref>
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<StructureSection load='3s5a' size='340' side='right'caption='[[3s5a]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3s5a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S5A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XL3:PROPANE-1-THIOL'>XL3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5a OCA], [https://pdbe.org/3s5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s5a RCSB], [https://www.ebi.ac.uk/pdbsum/3s5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s5a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALKB2_HUMAN ALKB2_HUMAN] Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.<ref>PMID:12486230</ref> <ref>PMID:12594517</ref> <ref>PMID:16174769</ref> <ref>PMID:18519673</ref> <ref>PMID:18432238</ref>
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==About this Structure==
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==See Also==
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[[3s5a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5A OCA].
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022659876</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, B.]]
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[[Category: Large Structures]]
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[[Category: Dinner, A R.]]
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[[Category: Chen B]]
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[[Category: He, C.]]
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[[Category: Dinner AR]]
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[[Category: Jia, G.]]
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[[Category: He C]]
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[[Category: Li, C Q.]]
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[[Category: Jia G]]
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[[Category: Qi, B.]]
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[[Category: Li CQ]]
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[[Category: Ramirez, B.]]
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[[Category: Qi B]]
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[[Category: Yang, C G.]]
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[[Category: Ramirez B]]
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[[Category: Yi, C.]]
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[[Category: Yang C-G]]
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[[Category: Zhang, L.]]
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[[Category: Yi C]]
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[[Category: Zhang, W.]]
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[[Category: Zhang L]]
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[[Category: Cross-linking]]
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[[Category: Zhang W]]
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[[Category: Dioxygenase]]
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[[Category: Dna binding]]
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[[Category: Double helix]]
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[[Category: Jelly-roll fold]]
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[[Category: Oxidoreductase-dna complex]]
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[[Category: Protein-dna complex]]
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Current revision

ABH2 cross-linked to undamaged dsDNA-2 with cofactors

PDB ID 3s5a

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