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4gh8
From Proteopedia
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| - | {{STRUCTURE_4gh8| PDB=4gh8 | SCENE= }} | ||
| - | ===Crystal structure of a 'humanized' E. coli dihydrofolate reductase=== | ||
| - | {{ABSTRACT_PUBMED_23733948}} | ||
| - | == | + | ==Crystal structure of a 'humanized' E. coli dihydrofolate reductase== |
| - | [[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI | + | <StructureSection load='4gh8' size='340' side='right'caption='[[4gh8]], [[Resolution|resolution]] 1.85Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gh8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GH8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gh8 OCA], [https://pdbe.org/4gh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gh8 RCSB], [https://www.ebi.ac.uk/pdbsum/4gh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gh8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Escherichia coli K-12]] | |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Benkovic SJ]] |
| - | [[Category: Benkovic | + | [[Category: French JB]] |
| - | [[Category: French | + | [[Category: Hammes-Schiffer S]] |
| - | [[Category: Hammes-Schiffer | + | [[Category: Hanoian P]] |
| - | [[Category: Hanoian | + | [[Category: Liu CT]] |
| - | [[Category: Liu | + | [[Category: Pringle TH]] |
| - | [[Category: Pringle | + | |
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Current revision
Crystal structure of a 'humanized' E. coli dihydrofolate reductase
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