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2i39

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[[Image:2i39.gif|left|200px]]<br /><applet load="2i39" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2i39, resolution 2.20&Aring;" />
 
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'''Crystal structure of Vaccinia virus N1L protein'''<br />
 
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==Overview==
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==Crystal structure of Vaccinia virus N1L protein==
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Poxviruses encode immuno-modulatory proteins capable of subverting host defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks detectable Bcl-2 homology (BH) motifs at the sequence level, we show that N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2 family proteins in vitro, consistent with a role for N1L in modulating host antiviral defenses.
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<StructureSection load='2i39' size='340' side='right'caption='[[2i39]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2i39]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I39 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i39 OCA], [https://pdbe.org/2i39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i39 RCSB], [https://www.ebi.ac.uk/pdbsum/2i39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i39 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q49PX0_9POXV Q49PX0_9POXV]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i3/2i39_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i39 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2I39 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus] with <scene name='pdbligand=MPD:'>MPD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I39 OCA].
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein., Aoyagi M, Zhai D, Jin C, Aleshin AE, Stec B, Reed JC, Liddington RC, Protein Sci. 2007 Jan;16(1):118-24. Epub 2006 Nov 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17123957 17123957]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Vaccinia virus]]
[[Category: Vaccinia virus]]
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[[Category: Aleshin, A E.]]
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[[Category: Aleshin AE]]
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[[Category: Aoyagi, M.]]
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[[Category: Aoyagi M]]
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[[Category: Liddington, R C.]]
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[[Category: Liddington RC]]
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[[Category: Stec, B.]]
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[[Category: Stec B]]
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[[Category: MPD]]
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[[Category: all alpha]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:48:37 2008''
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Current revision

Crystal structure of Vaccinia virus N1L protein

PDB ID 2i39

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OCA

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