3w0s

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'''Unreleased structure'''
 
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The entry 3w0s is ON HOLD until Paper Publication
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==Crystal structure of aminoglycoside phosphotransferase APH(4)-Ia, ternary complex with AMP-PNP and hygromycin B==
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<StructureSection load='3w0s' size='340' side='right'caption='[[3w0s]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
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Authors: Iino, D., Takakura, Y., Fukano, K., Sasaki, Y., Hoshino, T., Ohsawa, K., Nakamura, A., Yajima, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3w0s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W0S FirstGlance]. <br>
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Description: Crystal structure of aminoglycoside phosphotransferase APH(4)-Ia, ternary complex with AMP-PNP and hygromycin B
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=HY0:HYGROMYCIN+B+VARIANT'>HY0</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w0s OCA], [https://pdbe.org/3w0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w0s RCSB], [https://www.ebi.ac.uk/pdbsum/3w0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w0s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KHYB_ECOLX KHYB_ECOLX] The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation. Only phosphorylates hygromycin and closely related compounds such as demethyl analogs and destomycin.
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Fukano K]]
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[[Category: Hoshino T]]
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[[Category: Iino D]]
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[[Category: Nakamura A]]
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[[Category: Ohsawa K]]
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[[Category: Sasaki Y]]
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[[Category: Takakura Y]]
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[[Category: Yajima S]]

Current revision

Crystal structure of aminoglycoside phosphotransferase APH(4)-Ia, ternary complex with AMP-PNP and hygromycin B

PDB ID 3w0s

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