4bvc
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4bvc is ON HOLD Authors: Sandmark, J., Althage, M., Andersson, G.M.K., Antonsson, T., Blaho, S., Bodin, C., Bostrom, J., Chen, Y., Dahlen, A., Eriks...) |
|||
| (8 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.== | |
| - | + | <StructureSection load='4bvc' size='340' side='right'caption='[[4bvc]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4bvc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BVC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BV5:3-(4-PIPERIDYL)-N-[2-(TRIFLUOROMETHOXY)PHENYL]SULFONYL-PROPANAMIDE'>BV5</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bvc OCA], [https://pdbe.org/4bvc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bvc RCSB], [https://www.ebi.ac.uk/pdbsum/4bvc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bvc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/APOA_HUMAN APOA_HUMAN] Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.<ref>PMID:2531657</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Althage M]] | ||
| + | [[Category: Andersson GMK]] | ||
| + | [[Category: Antonsson T]] | ||
| + | [[Category: Blaho S]] | ||
| + | [[Category: Bodin C]] | ||
| + | [[Category: Bostrom J]] | ||
| + | [[Category: Chen Y]] | ||
| + | [[Category: Dahlen A]] | ||
| + | [[Category: Eriksson PO]] | ||
| + | [[Category: Evertsson E]] | ||
| + | [[Category: Fex T]] | ||
| + | [[Category: Fjellstrom O]] | ||
| + | [[Category: Gustafsson D]] | ||
| + | [[Category: Hallberg C]] | ||
| + | [[Category: Hicks R]] | ||
| + | [[Category: Jarkvist E]] | ||
| + | [[Category: Johansson C]] | ||
| + | [[Category: Kalies I]] | ||
| + | [[Category: Kang D]] | ||
| + | [[Category: Kartberg F]] | ||
| + | [[Category: Knecht W]] | ||
| + | [[Category: Legnehed A]] | ||
| + | [[Category: Lindqvist AM]] | ||
| + | [[Category: Martinsson SA]] | ||
| + | [[Category: Moberg A]] | ||
| + | [[Category: Petersson AU]] | ||
| + | [[Category: Ridderstrom M]] | ||
| + | [[Category: Sandmark J]] | ||
| + | [[Category: Svalstedt Karlsson B]] | ||
| + | [[Category: Thelin A]] | ||
| + | [[Category: Tigerstrom A]] | ||
| + | [[Category: Vinblad J]] | ||
| + | [[Category: Xu B]] | ||
Current revision
Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.
| |||||||||||
Categories: Homo sapiens | Large Structures | Althage M | Andersson GMK | Antonsson T | Blaho S | Bodin C | Bostrom J | Chen Y | Dahlen A | Eriksson PO | Evertsson E | Fex T | Fjellstrom O | Gustafsson D | Hallberg C | Hicks R | Jarkvist E | Johansson C | Kalies I | Kang D | Kartberg F | Knecht W | Legnehed A | Lindqvist AM | Martinsson SA | Moberg A | Petersson AU | Ridderstrom M | Sandmark J | Svalstedt Karlsson B | Thelin A | Tigerstrom A | Vinblad J | Xu B
