4jek

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'''Unreleased structure'''
 
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The entry 4jek is ON HOLD until Paper Publication
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==Structure of dibenzothiophene monooxygenase (DszC) from Rhodococcus erythropolis==
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<StructureSection load='4jek' size='340' side='right'caption='[[4jek]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors: Zhang, L., Duan, X.L., Zhou, D.M., Li, X.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4jek]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp._IGTS8 Rhodococcus sp. IGTS8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JEK FirstGlance]. <br>
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Description: Structure of dibenzothiophene monooxygenase (DszC) from Rhodococcus erythropolis
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jek OCA], [https://pdbe.org/4jek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jek RCSB], [https://www.ebi.ac.uk/pdbsum/4jek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jek ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DSZC_RHOSG DSZC_RHOSG] Catalyzes the first step of the '4S' desulfurization pathway that removes covalently bound sulfur from dibenzothiophene (DBT) without breaking carbon-carbon bonds. Sulfur dioxygenase which converts DBT to DBT-sulfone (DBTO2 or DBT 5,5-dioxide) in a stepwise manner. In (PubMed:7961424) DBTO (dibenzothiophene-5-oxide) was reported not to be a substrate, in (PubMed:7574582, PubMed:9634856, PubMed:8824615 and PubMed:9308179) it is reported to be a substrate (PubMed:7961424, PubMed:7574582, PubMed:9634856, PubMed:8824615, PubMed:9308179). Can also use benzyl sulfide and benzyl sulfoxide as substrates, although benzyl sulfoxide is a poor substrate (PubMed:8824615). The pathway substrate specificity has been augmented using mutagenesis, however no mutations allowed use of alkylated thiophenes (PubMed:11823208).<ref>PMID:11823208</ref> <ref>PMID:7574582</ref> <ref>PMID:7961424</ref> <ref>PMID:8824615</ref> <ref>PMID:9308179</ref> <ref>PMID:9634856</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Rhodococcus sp. IGTS8]]
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[[Category: Duan XL]]
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[[Category: Li X]]
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[[Category: Zhang L]]
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[[Category: Zhou DM]]

Current revision

Structure of dibenzothiophene monooxygenase (DszC) from Rhodococcus erythropolis

PDB ID 4jek

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