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4lc7
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4lc7 is ON HOLD Authors: Huestis M.P., Liu W., Volgraf M., Purkey H.E., Wu C., Wang W., Smith D., Vigers G.P.A., Dutcher D., Hunt K.W., Siu M. Desc...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Aminooxazoline inhibitor of BACE-1== | |
| + | <StructureSection load='4lc7' size='340' side='right'caption='[[4lc7]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4lc7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LC7 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1WP:(3AR,7AR)-3A-[3-(5-CHLOROPYRIDIN-3-YL)PHENYL]-3A,4,5,6,7,7A-HEXAHYDRO-1,3-BENZOXAZOL-2-AMINE'>1WP</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lc7 OCA], [https://pdbe.org/4lc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lc7 RCSB], [https://www.ebi.ac.uk/pdbsum/4lc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lc7 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Beta secretase 3D structures|Beta secretase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dutcher D]] | ||
| + | [[Category: Huestis MP]] | ||
| + | [[Category: Hunt KW]] | ||
| + | [[Category: Liu W]] | ||
| + | [[Category: Purkey HE]] | ||
| + | [[Category: Siu M]] | ||
| + | [[Category: Smith D]] | ||
| + | [[Category: Vigers GPA]] | ||
| + | [[Category: Volgraf M]] | ||
| + | [[Category: Wang W]] | ||
| + | [[Category: Wu C]] | ||
Current revision
Aminooxazoline inhibitor of BACE-1
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Categories: Homo sapiens | Large Structures | Dutcher D | Huestis MP | Hunt KW | Liu W | Purkey HE | Siu M | Smith D | Vigers GPA | Volgraf M | Wang W | Wu C
