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4kbl
From Proteopedia
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| - | {{STRUCTURE_4kbl| PDB=4kbl | SCENE= }} | ||
| - | ===Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism=== | ||
| - | {{ABSTRACT_PUBMED_23707686}} | ||
| - | == | + | ==Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism== |
| - | [[http://www.uniprot.org/uniprot/ARI1_HUMAN ARI1_HUMAN | + | <StructureSection load='4kbl' size='340' side='right'caption='[[4kbl]], [[Resolution|resolution]] 3.30Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4kbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KBL FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kbl OCA], [https://pdbe.org/4kbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kbl RCSB], [https://www.ebi.ac.uk/pdbsum/4kbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kbl ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ARI1_HUMAN ARI1_HUMAN] E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of EIF4E2, leading to its subsequent degradation.<ref>PMID:14623119</ref> <ref>PMID:21532592</ref> <ref>PMID:15236971</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Duda DM]] |
| - | [[Category: | + | [[Category: Olszewski JL]] |
| - | [[Category: | + | [[Category: Schulman BA]] |
| - | + | ||
| - | + | ||
Current revision
Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism
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