4k4x

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{{STRUCTURE_4k4x| PDB=4k4x | SCENE= }}
 
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===Coxsackievirus B3 polymerase elongation complex (r2_form), rna===
 
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{{ABSTRACT_PUBMED_23667424}}
 
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==Function==
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==Coxsackievirus B3 polymerase elongation complex (r2_form), rna==
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[[http://www.uniprot.org/uniprot/Q66338_9ENTO Q66338_9ENTO]] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS001676_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS001676_004_010047]
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<StructureSection load='4k4x' size='340' side='right'caption='[[4k4x]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4k4x]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_B3 Coxsackievirus B3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K4X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k4x OCA], [https://pdbe.org/4k4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k4x RCSB], [https://www.ebi.ac.uk/pdbsum/4k4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k4x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5UEA2_9ENTO Q5UEA2_9ENTO]
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==About this Structure==
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==See Also==
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[[4k4x]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_coxsackievirus_b3 Human coxsackievirus b3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K4X OCA].
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:023667424</ref><references group="xtra"/><references/>
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[[Category: Coxsackievirus B3]]
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[[Category: Human coxsackievirus b3]]
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[[Category: Large Structures]]
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[[Category: Gong, P.]]
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[[Category: Gong P]]
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[[Category: Peersen, O B.]]
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[[Category: Peersen OB]]
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[[Category: Polymerase]]
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[[Category: Protein-rna complex]]
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[[Category: Rna-dependent rna polymerase]]
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[[Category: Transferase-rna complex]]
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Current revision

Coxsackievirus B3 polymerase elongation complex (r2_form), rna

PDB ID 4k4x

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