1l3x

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{{STRUCTURE_1l3x| PDB=1l3x | SCENE= }}
 
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===Solution Structure of Novel Disintegrin Salmosin===
 
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{{ABSTRACT_PUBMED_14661951}}
 
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==Function==
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==Solution Structure of Novel Disintegrin Salmosin==
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[[http://www.uniprot.org/uniprot/VM2HS_GLOBR VM2HS_GLOBR]] Metalloproteinase hxl-1: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity).<ref>PMID:9722022</ref> <ref>PMID:9856345</ref> <ref>PMID:10446992</ref> <ref>PMID:10944460</ref> <ref>PMID:14977354</ref> Disintegrin salmosin-1: inhibits GPIIb/GPIIIa (ITGA2B/ITGB3) binding to immobilized fibrinogen with an IC(50) of 2.2 nM and ADP-induced platelet aggregation with an IC(50) of 131 nM, respectively. Inhibits angiogenesis.<ref>PMID:9722022</ref> <ref>PMID:9856345</ref> <ref>PMID:10446992</ref> <ref>PMID:10944460</ref> <ref>PMID:14977354</ref>
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<StructureSection load='1l3x' size='340' side='right'caption='[[1l3x]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1l3x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloydius_brevicaudus Gloydius brevicaudus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1iq2 1iq2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L3X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L3X FirstGlance]. <br>
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[[1l3x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloydius_brevicaudus Gloydius brevicaudus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1iq2 1iq2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L3X OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l3x OCA], [https://pdbe.org/1l3x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l3x RCSB], [https://www.ebi.ac.uk/pdbsum/1l3x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l3x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VM2HS_GLOBR VM2HS_GLOBR] Metalloproteinase hxl-1: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity).<ref>PMID:9722022</ref> <ref>PMID:9856345</ref> <ref>PMID:10446992</ref> <ref>PMID:10944460</ref> <ref>PMID:14977354</ref> Disintegrin salmosin-1: inhibits GPIIb/GPIIIa (ITGA2B/ITGB3) binding to immobilized fibrinogen with an IC(50) of 2.2 nM and ADP-induced platelet aggregation with an IC(50) of 131 nM, respectively. Inhibits angiogenesis.<ref>PMID:9722022</ref> <ref>PMID:9856345</ref> <ref>PMID:10446992</ref> <ref>PMID:10944460</ref> <ref>PMID:14977354</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l3/1l3x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l3x ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Disintegrin|Disintegrin]]
*[[Disintegrin|Disintegrin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:014661951</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Gloydius brevicaudus]]
[[Category: Gloydius brevicaudus]]
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[[Category: Lee, W.]]
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[[Category: Large Structures]]
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[[Category: Shin, J.]]
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[[Category: Lee W]]
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[[Category: Disintegrin]]
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[[Category: Shin J]]
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[[Category: Protein binding]]
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[[Category: Rgd]]
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[[Category: Snake venome]]
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Current revision

Solution Structure of Novel Disintegrin Salmosin

PDB ID 1l3x

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