3ums
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| - | {{STRUCTURE_3ums| PDB=3ums | SCENE= }} | ||
| - | ===Crystal structure of the G202A mutant of human G-alpha-i1=== | ||
| - | {{ABSTRACT_PUBMED_20351284}} | ||
| - | == | + | ==Crystal structure of the G202A mutant of human G-alpha-i1== |
| - | [[ | + | <StructureSection load='3ums' size='340' side='right'caption='[[3ums]], [[Resolution|resolution]] 2.34Å' scene=''> |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3ums]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2pz2 2pz2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UMS FirstGlance]. <br> | |
| - | [[3ums]] is a 1 chain structure with sequence from [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.343Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ums FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ums OCA], [https://pdbe.org/3ums PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ums RCSB], [https://www.ebi.ac.uk/pdbsum/3ums PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ums ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | == | + | [https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> |
| - | < | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Cappell | + | [[Category: Large Structures]] |
| - | [[Category: Johnston | + | [[Category: Cappell SD]] |
| - | [[Category: Kimple | + | [[Category: Johnston CA]] |
| - | [[Category: Kuravi | + | [[Category: Kimple AJ]] |
| - | [[Category: Lambert | + | [[Category: Kuravi S]] |
| - | [[Category: Siderovski | + | [[Category: Lambert NA]] |
| - | [[Category: Willard | + | [[Category: Siderovski DP]] |
| - | + | [[Category: Willard FS]] | |
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Current revision
Crystal structure of the G202A mutant of human G-alpha-i1
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