2i7q

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[[Image:2i7q.gif|left|200px]]<br /><applet load="2i7q" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2i7q, resolution 1.900&Aring;" />
 
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'''Crystal structure of Human Choline Kinase A'''<br />
 
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==Disease==
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==Crystal structure of Human Choline Kinase A==
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Known diseases associated with this structure: Breast and colorectal cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604373 604373]], Breast cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604373 604373]], Li-Fraumeni syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604373 604373]], Osteosarcoma, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604373 604373]], Prostate cancer, familial OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604373 604373]]
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<StructureSection load='2i7q' size='340' side='right'caption='[[2i7q]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2i7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I7Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7q OCA], [https://pdbe.org/2i7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i7q RCSB], [https://www.ebi.ac.uk/pdbsum/2i7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i7q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i7/2i7q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i7q ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2I7Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=UNX:'>UNX</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Choline_kinase Choline kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.32 2.7.1.32] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7Q OCA].
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*[[Choline kinase 3D structures|Choline kinase 3D structures]]
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[[Category: Choline kinase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Landry, R.]]
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[[Category: Landry R]]
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[[Category: Nedyalkova, L.]]
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[[Category: Nedyalkova L]]
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[[Category: Park, H.]]
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[[Category: Park H]]
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[[Category: Rabeh, W M.]]
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[[Category: Rabeh WM]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Tempel W]]
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[[Category: Tempel, W.]]
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[[Category: Wasney G]]
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[[Category: Wasney, G.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: CL]]
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[[Category: UNX]]
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[[Category: choline kinase]]
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[[Category: non-protein kinase]]
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[[Category: sgc]]
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:49:59 2008''
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Current revision

Crystal structure of Human Choline Kinase A

PDB ID 2i7q

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