4bjs

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{{STRUCTURE_4bjs| PDB=4bjs | SCENE= }}
 
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===Crystal structure of the Rif1 C-terminal domain (Rif1-CTD) from Saccharomyces cerevisiae===
 
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{{ABSTRACT_PUBMED_23746845}}
 
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==Function==
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==Crystal structure of the Rif1 C-terminal domain (Rif1-CTD) from Saccharomyces cerevisiae==
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[[http://www.uniprot.org/uniprot/RIF1_YEAST RIF1_YEAST]] Negatively regulates telomere length by preventing telomere elongation or promoting degradation of the telomere ends. Recruited to telomeres by interaction with the C-terminus of RAP1, which binds directly to telomeric repeat DNA. This may create a negative feedback loop in which the addition of new telomere repeats creates binding sites for inhibitors of telomere length extension. May also influence the balance of transcriptional silencing at telomeres and the silent mating type locus HMR, which is mediated by SIR (Silent Information Regulator) proteins including SIR3 and SIR4. RIF1 competes with SIR proteins for binding to the C-terminus of RAP1. In the absence of RIF1, a limiting cellular pool of SIR proteins may preferentially associate with RAP1 at sub-telomeric loci, causing enhanced telomeric silencing and attenuated silencing of the HMR locus.<ref>PMID:1577274</ref> <ref>PMID:7867933</ref> <ref>PMID:9087429</ref> <ref>PMID:10531008</ref> <ref>PMID:15572688</ref>
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<StructureSection load='4bjs' size='340' side='right'caption='[[4bjs]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4bjs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BJS FirstGlance]. <br>
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[[4bjs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJS OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjs OCA], [https://pdbe.org/4bjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bjs RCSB], [https://www.ebi.ac.uk/pdbsum/4bjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bjs ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:023746845</ref><references group="xtra"/><references/>
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== Function ==
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[[Category: Saccharomyces cerevisiae s288c]]
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[https://www.uniprot.org/uniprot/RIF1_YEAST RIF1_YEAST] Negatively regulates telomere length by preventing telomere elongation or promoting degradation of the telomere ends. Recruited to telomeres by interaction with the C-terminus of RAP1, which binds directly to telomeric repeat DNA. This may create a negative feedback loop in which the addition of new telomere repeats creates binding sites for inhibitors of telomere length extension. May also influence the balance of transcriptional silencing at telomeres and the silent mating type locus HMR, which is mediated by SIR (Silent Information Regulator) proteins including SIR3 and SIR4. RIF1 competes with SIR proteins for binding to the C-terminus of RAP1. In the absence of RIF1, a limiting cellular pool of SIR proteins may preferentially associate with RAP1 at sub-telomeric loci, causing enhanced telomeric silencing and attenuated silencing of the HMR locus.<ref>PMID:1577274</ref> <ref>PMID:7867933</ref> <ref>PMID:9087429</ref> <ref>PMID:10531008</ref> <ref>PMID:15572688</ref>
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[[Category: Bunker, R D.]]
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== References ==
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[[Category: Gut, H.]]
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<references/>
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[[Category: Scrima, A.]]
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__TOC__
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[[Category: Shi, T.]]
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</StructureSection>
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[[Category: Thoma, N H.]]
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[[Category: Large Structures]]
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[[Category: Cell cycle]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Telomere associated protein]]
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[[Category: Bunker RD]]
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[[Category: Gut H]]
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[[Category: Scrima A]]
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[[Category: Shi T]]
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[[Category: Thoma NH]]

Current revision

Crystal structure of the Rif1 C-terminal domain (Rif1-CTD) from Saccharomyces cerevisiae

PDB ID 4bjs

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