This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2i9p

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:07, 30 August 2023) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2i9p.gif|left|200px]]<br /><applet load="2i9p" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2i9p, resolution 2.55&Aring;" />
 
-
'''Crystal structure of human hydroxyisobutyrate dehydrogenase complexed with NAD+'''<br />
 
-
==About this Structure==
+
==Crystal structure of human hydroxyisobutyrate dehydrogenase complexed with NAD+==
-
2I9P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAD:'>NAD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/3-hydroxyisobutyrate_dehydrogenase 3-hydroxyisobutyrate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.31 1.1.1.31] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I9P OCA].
+
<StructureSection load='2i9p' size='340' side='right'caption='[[2i9p]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
-
[[Category: 3-hydroxyisobutyrate dehydrogenase]]
+
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2i9p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I9P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I9P FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i9p OCA], [https://pdbe.org/2i9p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i9p RCSB], [https://www.ebi.ac.uk/pdbsum/2i9p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i9p ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/3HIDH_HUMAN 3HIDH_HUMAN]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i9/2i9p_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i9p ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C.]]
+
[[Category: Arrowsmith C]]
-
[[Category: Burgess, N.]]
+
[[Category: Burgess N]]
-
[[Category: Delft, F Von.]]
+
[[Category: Edwards A]]
-
[[Category: Edwards, A.]]
+
[[Category: Kavanagh KL]]
-
[[Category: Kavanagh, K L.]]
+
[[Category: Lukacik P]]
-
[[Category: Lukacik, P.]]
+
[[Category: Oppermann U]]
-
[[Category: Oppermann, U.]]
+
[[Category: Papagrigoriou E]]
-
[[Category: Papagrigoriou, E.]]
+
[[Category: Salah E]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Smee C]]
-
[[Category: Salah, E.]]
+
[[Category: Sundstrom M]]
-
[[Category: Smee, C.]]
+
[[Category: Weigelt J]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Von Delft F]]
-
[[Category: Weigelt, J.]]
+
-
[[Category: NAD]]
+
-
[[Category: 3-hydroxyacid dehydrogenase]]
+
-
[[Category: sgc]]
+
-
[[Category: structural genomics]]
+
-
[[Category: structural genomics consortium]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:50:21 2008''
+

Current revision

Crystal structure of human hydroxyisobutyrate dehydrogenase complexed with NAD+

PDB ID 2i9p

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2i9p"
Personal tools