Nebulin
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1neb' size='350' side='right' caption='NMR structure of human nebulin SH3 domain (PDB entry 1neb)' scene=''> '''Nebulin''' is an actin-binding protein whic...) |
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<StructureSection load='1neb' size='350' side='right' caption='NMR structure of human nebulin SH3 domain (PDB entry [[1neb]])' scene=''> | <StructureSection load='1neb' size='350' side='right' caption='NMR structure of human nebulin SH3 domain (PDB entry [[1neb]])' scene=''> | ||
| - | + | == Function == | |
| - | '''Nebulin''' is an actin-binding protein which can bind upto 200 actin molecules. Nebulin length is proportional to the length of the thin filament. It may function as a regulator of thin filament length during sarcomere assembly. For more details see [[Group:MUZIC:Nebulin]]. | + | '''Nebulin''' is an actin-binding protein which can bind upto 200 actin molecules. Nebulin length is proportional to the length of the thin filament. It may function as a regulator of thin filament length during sarcomere assembly<ref>PMID:21115852</ref>. |
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| + | For more details see [[Group:MUZIC:Nebulin]]. | ||
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| + | == Disease == | ||
| + | Mutations in nebulin were identified in patients with nemaline myopathy<ref>PMID:11257471</ref>. | ||
==3D structures of nebulin== | ==3D structures of nebulin== | ||
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[[1neb]] – hNebulin SH3 domain residues 918-977 – human - NMR <br /> | [[1neb]] – hNebulin SH3 domain residues 918-977 – human - NMR <br /> | ||
[[1ark]] – hNebulin SH3 domain residues 6610-6669 - NMR <br /> | [[1ark]] – hNebulin SH3 domain residues 6610-6669 - NMR <br /> | ||
| + | [[7qin]] – mNebulin in actomyosin complex – mouse – Cryo EM<br /> | ||
| + | [[7qim]] – mNebulin + actin – Cryo EM<br /> | ||
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| + | == References == | ||
| + | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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