4gv3

{{STRUCTURE_4gv3| PDB=4gv3 | SCENE= }}

===Structures of Lassa and Tacaribe viral nucleoproteins with or without 5 triphosphate dsRNA substrate reveal a unique 3 -5 exoribonuclease mechanism to suppress type I interferon production===

{{ABSTRACT_PUBMED_23615902}}

==Function==

[[http://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).

==About this Structure==

[[4gv3]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lassa_virus_josiah Lassa virus josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV3 OCA].

 

<ref group="xtra">PMID:023615902</ref><references group="xtra"/><references/>

[[Category: Lassa virus josiah]]

[[Category: Dong, C.]]

[[Category: Dong, H.]]

[[Category: Huang, Q.]]

[[Category: Jiang, X.]]

[[Category: Liang, Y.]]

[[Category: Ly, H.]]

[[Category: Wang, W.]]

[[Category: Rna binding protein-rna complex]]