4gae

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{{STRUCTURE_4gae| PDB=4gae | SCENE= }}
 
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===Crystal structure of plasmodium dxr in complex with a pyridine-containing inhibitor===
 
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{{ABSTRACT_PUBMED_23795240}}
 
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==About this Structure==
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==Crystal structure of plasmodium dxr in complex with a pyridine-containing inhibitor==
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[[4gae]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_hb3 Plasmodium falciparum hb3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAE OCA].
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<StructureSection load='4gae' size='340' side='right'caption='[[4gae]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gae]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_HB3 Plasmodium falciparum HB3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GAE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FOB:[(1R)-3-[ACETYL(HYDROXY)AMINO]-1-(PYRIDIN-4-YL)PROPYL]PHOSPHONIC+ACID'>FOB</scene>, <scene name='pdbligand=FOQ:[(1S)-3-[ACETYL(HYDROXY)AMINO]-1-(PYRIDIN-4-YL)PROPYL]PHOSPHONIC+ACID'>FOQ</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gae OCA], [https://pdbe.org/4gae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gae RCSB], [https://www.ebi.ac.uk/pdbsum/4gae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gae ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DXR_PLAFX DXR_PLAFX] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).<ref>PMID:10477522</ref>
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==Reference==
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==See Also==
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<ref group="xtra">PMID:023795240</ref><references group="xtra"/><references/>
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*[[DXP reductoisomerase 3D Structures|DXP reductoisomerase 3D Structures]]
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[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
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== References ==
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[[Category: Plasmodium falciparum hb3]]
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<references/>
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[[Category: Cai, G.]]
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__TOC__
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[[Category: Deng, L.]]
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</StructureSection>
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[[Category: Diao, J.]]
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[[Category: Large Structures]]
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[[Category: Song, Y.]]
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[[Category: Plasmodium falciparum HB3]]
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[[Category: Xue, J.]]
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[[Category: Cai G]]
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[[Category: Isomerase-isomerase inhibitor complex]]
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[[Category: Deng L]]
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[[Category: Nadph binding]]
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[[Category: Diao J]]
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[[Category: Song Y]]
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[[Category: Xue J]]

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Crystal structure of plasmodium dxr in complex with a pyridine-containing inhibitor

PDB ID 4gae

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