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3u0r

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{{STRUCTURE_3u0r| PDB=3u0r | SCENE= }}
 
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===Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules===
 
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{{ABSTRACT_PUBMED_22334682}}
 
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==Function==
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==Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules==
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[[http://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN]] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref>
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<StructureSection load='3u0r' size='340' side='right'caption='[[3u0r]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3u0r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U0R FirstGlance]. <br>
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[[3u0r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0r OCA], [https://pdbe.org/3u0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u0r RCSB], [https://www.ebi.ac.uk/pdbsum/3u0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u0r ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:022334682</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cho, J W.]]
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[[Category: Large Structures]]
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[[Category: Han, B G.]]
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[[Category: Cho JW]]
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[[Category: Jeong, K C.]]
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[[Category: Han BG]]
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[[Category: Kim, K H.]]
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[[Category: Jeong KC]]
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[[Category: Kim, T W.]]
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[[Category: Kim KH]]
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[[Category: Lee, B I.]]
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[[Category: Kim TW]]
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[[Category: Lee, S H.]]
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[[Category: Lee BI]]
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[[Category: Noh, K H.]]
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[[Category: Lee SH]]
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[[Category: Suh, S W.]]
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[[Category: Noh KH]]
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[[Category: Yoon, H J.]]
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[[Category: Suh SW]]
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[[Category: Apoptosis inhibitor]]
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[[Category: Yoon HJ]]
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[[Category: Armadillo repeat]]
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[[Category: Heat repeat]]
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[[Category: Lysine acetylation]]
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Current revision

Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules

PDB ID 3u0r

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