4gr9
From Proteopedia
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| - | {{STRUCTURE_4gr9| PDB=4gr9 | SCENE= }} | ||
| - | ===Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation=== | ||
| - | {{ABSTRACT_PUBMED_23131339}} | ||
| - | == | + | ==Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation== |
| - | [[http://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN | + | <StructureSection load='4gr9' size='340' side='right'caption='[[4gr9]], [[Resolution|resolution]] 2.29Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gr9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GR9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.291Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=372:N-[(3R)-3-(CYANOMETHYL)-1-METHYL-2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL]ACETAMIDE'>372</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gr9 OCA], [https://pdbe.org/4gr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gr9 RCSB], [https://www.ebi.ac.uk/pdbsum/4gr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gr9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Quinone reductase 3D structures|Quinone reductase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Jensen | + | [[Category: Large Structures]] |
| - | [[Category: Lozinskaya | + | [[Category: Jensen KC]] |
| - | [[Category: Mesecar | + | [[Category: Lozinskaya NA]] |
| - | [[Category: Proskurnina | + | [[Category: Mesecar AD]] |
| - | [[Category: Sosonyuk | + | [[Category: Proskurnina MV]] |
| - | [[Category: Volkova | + | [[Category: Sosonyuk SE]] |
| - | [[Category: Zefirov | + | [[Category: Volkova MS]] |
| - | + | [[Category: Zefirov NS]] | |
| - | + | ||
Current revision
Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation
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