4kp6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:14, 1 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4kp6| PDB=4kp6 | SCENE= }}
 
-
===Crystal structure of human phosphodiesterase 4B (PDE4B) in complex with a [1,3,5]triazine derivative===
 
-
{{ABSTRACT_PUBMED_23806553}}
 
-
==Function==
+
==Crystal structure of human phosphodiesterase 4B (PDE4B) in complex with a [1,3,5]triazine derivative==
-
[[http://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>
+
<StructureSection load='4kp6' size='340' side='right'caption='[[4kp6]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4kp6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KP6 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1S1:2-ETHYL-2-{[4-(METHYLAMINO)-6-(1H-1,2,4-TRIAZOL-1-YL)-1,3,5-TRIAZIN-2-YL]AMINO}BUTANENITRILE'>1S1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kp6 OCA], [https://pdbe.org/4kp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kp6 RCSB], [https://www.ebi.ac.uk/pdbsum/4kp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kp6 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>
-
==About this Structure==
+
==See Also==
-
[[4kp6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP6 OCA].
+
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:023806553</ref><references group="xtra"/><references/>
+
__TOC__
-
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
+
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Egerland, U.]]
+
[[Category: Large Structures]]
-
[[Category: Gewald, R.]]
+
[[Category: Egerland U]]
-
[[Category: Grunwald, C.]]
+
[[Category: Gewald R]]
-
[[Category: Copd]]
+
[[Category: Grunwald C]]
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
-
[[Category: Neutrophilia]]
+
-
[[Category: Pde4 inhibitor]]
+
-
[[Category: Phosphodiesterase]]
+
-
[[Category: Triazine]]
+

Current revision

Crystal structure of human phosphodiesterase 4B (PDE4B) in complex with a [1,3,5]triazine derivative

PDB ID 4kp6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4kp6"
Personal tools