4fzs

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{{STRUCTURE_4fzs| PDB=4fzs | SCENE= }}
 
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===Structure of human SNX1 BAR domain===
 
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==Function==
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==Structure of human SNX1 BAR domain==
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[[http://www.uniprot.org/uniprot/SNX1_HUMAN SNX1_HUMAN]] May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).<ref>PMID:12198132</ref> <ref>PMID:15498486</ref> <ref>PMID:17101778</ref>
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<StructureSection load='4fzs' size='340' side='right'caption='[[4fzs]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fzs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FZS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fzs OCA], [https://pdbe.org/4fzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fzs RCSB], [https://www.ebi.ac.uk/pdbsum/4fzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fzs ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SNX1_HUMAN SNX1_HUMAN] May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).<ref>PMID:12198132</ref> <ref>PMID:15498486</ref> <ref>PMID:17101778</ref>
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==About this Structure==
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==See Also==
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[[4fzs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZS OCA].
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*[[Sorting nexin 3D structures|Sorting nexin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bhatia, V K.]]
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[[Category: Large Structures]]
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[[Category: Cullen, P J.]]
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[[Category: Bhatia VK]]
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[[Category: Hurley, J H.]]
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[[Category: Cullen PJ]]
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[[Category: Kloer, D P.]]
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[[Category: Hurley JH]]
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[[Category: Sessions, R B.]]
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[[Category: Kloer DP]]
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[[Category: Stamou, D.]]
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[[Category: Sessions RB]]
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[[Category: Traer, C J.]]
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[[Category: Stamou D]]
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[[Category: Weering, J R.T van.]]
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[[Category: Traer CJ]]
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[[Category: Bar]]
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[[Category: Van Weering JRT]]
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[[Category: Membrane remodeling]]
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[[Category: Protein transport]]
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Current revision

Structure of human SNX1 BAR domain

PDB ID 4fzs

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