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2iip

From Proteopedia

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[[Image:2iip.gif|left|200px]]<br /><applet load="2iip" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2iip, resolution 2.05&Aring;" />
 
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'''Human Nicotinamide N-methyltransferase'''<br />
 
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==Disease==
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==Human Nicotinamide N-methyltransferase==
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Known disease associated with this structure: Homocysteine plasma level OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600008 600008]]
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<StructureSection load='2iip' size='340' side='right'caption='[[2iip]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2iip]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IIP FirstGlance]. <br>
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2IIP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SAH:'>SAH</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Nicotinamide_N-methyltransferase Nicotinamide N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.1 2.1.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IIP OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iip OCA], [https://pdbe.org/2iip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iip RCSB], [https://www.ebi.ac.uk/pdbsum/2iip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iip ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NNMT_HUMAN NNMT_HUMAN] Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ii/2iip_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iip ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Nicotinamide N-methyltransferase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Avvakumov GV]]
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[[Category: Avvakumov, G V.]]
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[[Category: Bernstein G]]
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[[Category: Bernstein, G.]]
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[[Category: Bochkarev A]]
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[[Category: Bochkarev, A.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Loppnau P]]
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[[Category: Loppnau, P.]]
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[[Category: Min J]]
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[[Category: Min, J.]]
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[[Category: Plotnikov AN]]
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[[Category: Plotnikov, A N.]]
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[[Category: Sundstrom M]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Tempel W]]
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[[Category: Sundstrom, M.]]
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[[Category: Wasney G]]
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[[Category: Tempel, W.]]
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[[Category: Weigelt J]]
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[[Category: Wasney, G.]]
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[[Category: Wu H]]
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[[Category: Weigelt, J.]]
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[[Category: Zeng H]]
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[[Category: Wu, H.]]
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[[Category: Zeng, H.]]
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[[Category: SAH]]
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[[Category: methyltransferase]]
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[[Category: mutant]]
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[[Category: mutation]]
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[[Category: sgc]]
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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[[Category: surface mutagenesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:53:07 2008''
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Current revision

Human Nicotinamide N-methyltransferase

PDB ID 2iip

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