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Preprotein translocase

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<StructureSection load='2yxr' size='350' side='right' caption='Structure of preprotein translocase subunits SecY (grey), SecE (green), SecG (pink) (PDB entry [[2yxr]])' scene=''>
<StructureSection load='2yxr' size='350' side='right' caption='Structure of preprotein translocase subunits SecY (grey), SecE (green), SecG (pink) (PDB entry [[2yxr]])' scene=''>
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== Function ==
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'''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor<ref>PMID:9489663</ref>. The translocase pathway contains:<br />
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*'''SecB''' - a chaperone protein<ref>PMID:9767586</ref> <br />
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*'''SecY, SecE, SecG''' or '''Sec61''' an integral membrane complex<br />
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*'''SecD, SecF''' - proteins promoting the release of the mature peptide into the periplasm<br />
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*'''SecA''' - an ATPase unit<ref>PMID:10617931</ref>.<br />
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'''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor. The translocase pathway contains a chaperone protein – '''SecB'''; an integral membrane complex – '''SecY, SecE, SecG;''' proteins promoting the release of the mature peptide into the periplasm – '''SecD, SecF'''; and ATPase unit - '''SecA'''. For more details see [[SecA PBD motions]].
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For more details see [[SecA PBD motions]].
==3D structures of preprotein translocase==
==3D structures of preprotein translocase==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[Preprotein translocase 3D structures]]
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[[1rh5]], [[1rhz]] – MjPPT SecY + SecE + SecB – ''Methanocaldococcus jannaschii'' <br />
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== References ==
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[[2akh]], [[2aki]] – EcPPT SecY + SecE + SecG – ''Escherichia coli'' - CryoEM <br />
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<references/>
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[[2yxq]], [[2yxr]] – MjPPT SecY + SecE + SecG <br />
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</StructureSection>
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[[3mp7]] – PPT SecY + SecE – ''Pyrococcus furiosus'' <br />
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[[3dkn]] – PPT SecY + SecE + SecG + RNA – dog - CryoEM <br />
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[[3din]] – TmPPT SecY + SecE + SecG + SecA – ''Thermotoga maritima''<br />
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[[2zjs]] – TtPPT SecY + SecE + antibody – ''Thermus thermophilus''<br />
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[[2zqp]] – TtPPT SecY + SecE <br />
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[[3dl8]] – PPT SecY + SecE + SecA + SecG – ''Aquifex aeolicus'' - CryoEM<br />
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[[3bo0]], [[3bo1]] – EcPPT SecY + SecE + SecG + 23S ribosomal RNA - CryoEM<br />
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[[3kcr]] – EcPPT SecY + SecE + SecG + large ribosomal subunit - CryoEM<br />
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[[3j01]] – EcPPT SecY + SecE + large ribosomal subunit - CryoEM<br />
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'''PPT SecA'''
 
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[[1m6n]], [[1tf5]], [[2ibm]] – BsPPT SecA – ''Bacillus subtilis'' <br />
 
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[[3iqm]], [[3iqy]] – BsPPT SecA (mutant)<br />
 
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[[1tm6]] – EcPPT SecA C terminal - NMR<br />
 
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[[2ipc]] – TtPPT SecA<br />
 
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[[3jux]] – TmPPT SecA<br />
 
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[[2fsf]] – EcPPT SecA<br />
 
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[[2fsf]] – EcPPT SecA<br />
 
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[[3bxz]] – EcPPT SecA dead motor domains (mutant)<br />
 
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''PPT SecA complex''
 
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[[1m74]], [[1tf2]] – BsPPT SecA + Mg + ADP <br />
 
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[[1ozb]] – PPT SecA C terminal + SecB - ''Haemophilus influenzae''<br />
 
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[[2fsh]] – EcPPT SecA + AMPPNP<br />
 
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[[2fsi]] – EcPPT SecA + ADP<br />
 
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[[2vda]] – EcPPT SecA + maltoporin signal peptide - NMR<br />
 
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[[3jv2]] – BsPPT SecA + peptide <br />
 
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of preprotein translocase subunits SecY (grey), SecE (green), SecG (pink) (PDB entry 2yxr)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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