Dehydroquinase

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<StructureSection load='4gui' size='350' side='right' caption='Structure of dehydroquinase type I complex with shikimate and Ni+2 ion (PDB entry [[4gui]])' scene=''>
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<StructureSection load='4gui' size='350' side='right' caption='Structure of dehydroquinase type I complex with quinate and Ni+2 ion (PDB entry [[4gui]])' scene='55/553960/Cv/2'>
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== Function ==
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'''Dehydroquinase''' (DHQD) catalyzes the conversion of 3-hydroquinate to 3-hydroshikumate. DHQD is part of the shikimate pathway by which bacteria synthesize the aromatic amino acids. There are 2 types of DHQD found in different organisms. They differ in their sequence and structure. Inhibitors of DHQD are potential bacteriocides.
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'''Dehydroquinase''' (DHQD) catalyzes the conversion of 3-hydroquinate to 3-hydroshikimate. DHQD is part of the shikimate pathway by which bacteria synthesize the aromatic amino acids. There are 2 types of DHQD found in different organisms. They differ in their sequence and structure. <ref>PMID:12242393</ref>
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==3D structures of dehydroquinase==
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== Relevance ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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Inhibitors of DHQD are potential bacteriocides.<ref>PMID:21410435</ref>
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'''DHQD-I'''
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== Structural highlights ==
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[[1qfe]], [[1gqn]], [[3l2i]], [[3oex]], [[4gfs]] – StDHQD – ''Salmonella typhi'' <br />
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The structure of dehydroquinase type I complex with quinate shows <scene name='55/553960/Cv/10'>DHQD as a homodimer</scene>. The binding of quinate in <scene name='55/553960/Cv/11'>monomer A is slightly different than in monomer B</scene>.<ref>PMID:24437575</ref> <scene name='55/553960/Cv/12'>Click here to see the animation of this scene</scene>.
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[[3o1n]], [[4guf]] – StDHQD (mutant) <br />
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[[1sfl]] – SaDHQD – ''Staphylococcus aureus''<br />
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[[2ocz]] – DHQD – ''Streptococcus pyrogenes''<br />
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[[2egz]], [[2ysw]] – DHQD – ''Aquifex aeolicus''<br />
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[[2yr1]] – DHQD – ''Geobacillus kaustophilus''<br />
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[[2ox1]] – DHQD – ''Archaeoglobus fulgidus''<br />
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[[3l9c]] – DHQD – ''Streptococcus mutans''<br />
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''DHQD-I complexes''
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==3D structures of dehydroquinase==
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[[Dehydroquinase 3D structures]]
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[[1l9w]] – StDHQD + amino-dehydroxy-cyclohex-enecarboxylate <br />
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[[1sfj]] – SaDHQD + dehydroquinic acid <br />
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[[3js3]] – CdDHQD + amino-dehydroxy-cyclohex-enecarboxylate – ''Clostridium difficile''<br />
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[[3lb0]] – StDHQD + citrate<br />
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[[3s42]] – StDHQD + borate + malonate<br />
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[[3m7w]] – StDHQD + dehydroquinic acid <br />
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[[4gui]] – StDHQD + quinic acid <br />
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[[4iuo]] – StDHQD (mutant) + quinic acid <br />
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[[3nnt]] – StDHQD (mutant) + dehydroquinic acid <br />
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[[4gug]], [[4guh]] – StDHQD (mutant) + dehydroshikimate<br />
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[[4guj]] – StDHQD + shikimate<br />
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[[4h3d]] – CdDHQD + comenic acid <br />
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'''DHQD-II'''
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[[1d0i]], [[1gu0]] – ScDHQD – ''Streptomyces coelicolor'' <br />
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[[2dhq]], [[1h05]] – MtDHQD – ''Mycobacterium tuberculosis'' <br />
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[[1gqo]] – DHQD – ''Bacillus subtilis'' <br />
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[[1uqr]] – DHQD – ''Actinobacillus pleuropneumoniae''<br />
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[[2uyg]] – DHQD – ''Thermus thermoophilus''<br />
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[[3lwz]] – DHQD – ''Yersinia pestis''<br />
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[[3kip]] – DHQD – ''Candida albicans''<br />
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[[3u80]] – DHQD – ''Bifidobacterium longum'' <br />
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''DHQD-II complexes''
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</StructureSection>
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[[1gu1]] – ScDHQD + anhydroquinic acid<br />
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== References ==
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[[1v1j]] – ScDHQD + anhydrofluoroquinic acid<br />
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<references/>
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[[2bt4]], [[2cjf]] – ScDHQD + inhibitor<br />
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[[Category:Topic Page]]
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[[1gtz]] – ScDHQD (mutant) + dehydroshikimate<br />
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[[1j2y]] – HpDHQD + dehydroquinic acid – ''Helicobacter pylori''<br />
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[[1h0s]] – MtDHQD + hydroxyl-imino-quinic acid<br />
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[[1h0r]] – MtDHQD + anhydroquinic acid<br />
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[[2c4v]] – HpDHQD + citrate<br />
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[[2c4w]], [[2c57]], [[2wks]], [[2xb9]], [[2xd9]], [[2xda]], [[4b6r]], [[4b6s]] – HpDHQD + inhibitor<br />
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[[3n59]] – MtDHQD + dehydroshikimate<br />
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[[3n8k]] – MtDHQD + citrazinic acid<br />
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[[2xb8]], [[3n76]], [[3n7a]], [[3n86]], [[3n87]], [[3n8n]], [[2y71]], [[2y76]], [[2y77]], [[4b6o]], [[4b6p]], [[4b6q]] – MtDHQD + inhibitor<br />
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Current revision

Structure of dehydroquinase type I complex with quinate and Ni+2 ion (PDB entry 4gui)

Drag the structure with the mouse to rotate

References

  1. ↑ Herrmann KM. The Shikimate Pathway: Early Steps in the Biosynthesis of Aromatic Compounds. Plant Cell. 1995 Jul;7(7):907-919. PMID:12242393 doi:http://dx.doi.org/10.1105/tpc.7.7.907
  2. ↑ Dias MV, Snee WC, Bromfield KM, Payne R, Palaninathan SK, Ciulli A, Howard NI, Abell C, Sacchettini JC, Blundell TL. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. Biochem J. 2011 Mar 17. PMID:21410435 doi:10.1042/BJ20110002
  3. ↑ Light SH, Antanasijevic A, Krishna SN, Caffrey M, Anderson WF, Lavie A. Crystal structures of type I dehydroquinate dehydratase in complex with quinate and shikimate suggest a novel mechanism of Schiff base formation. Biochemistry. 2014 Feb 11;53(5):872-80. doi: 10.1021/bi4015506. Epub 2014 Jan 31. PMID:24437575 doi:http://dx.doi.org/10.1021/bi4015506

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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