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NF-kB

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<StructureSection load='1nfk' size='350' side='right' caption='Structure of human NF-kB1 p50 complex with DNA (PDB entry [[1nfk]])' scene=''>
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<StructureSection load='1nfk' size='350' side='right' caption='Structure of mouse NF-kB1 p50 complex with DNA (PDB entry [[1nfk]])' scene=''>
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== Function ==
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'''NF-kB''' or '''Nuclear Factor NF-kappa''' is a DNA transcription factor. It is involved in cellular response to stimuli. NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA. There are 5 proteins in the NF-kB family: '''NF-kB1''' (synthesized as '''p105''' and processed to '''p50'''), '''NF-kB2''' (synthesized as '''p100''' and processed to '''p52'''), '''RelA''' (or '''p65'''), '''RelB''' and '''cRel'''. I-κ-B-α is an inhibitor of NF-kB.
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'''NF-kB''' or '''Nuclear Factor NF-kappa''' is a DNA transcription factor. It is involved in cellular response to stimuli. NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA<ref>PMID:15371334</ref>. I-κ-B-α is an inhibitor of NF-kB.<br />
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There are 5 proteins in the NF-kB family:<br />
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*'''NF-kB1''' (synthesized as '''p105''' and processed to '''p50''')<br />
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*'''NF-kB2''' (synthesized as '''p100''' and processed to '''p52''')<br />
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*'''RelA''' (or '''p65''' subunit of NF-kB)<br />
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*'''RelB'''<br />
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*'''cRel'''.
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See also [[NF-kB (hebrew)]].
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== Relevance ==
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NF-kB plays a critical role in cancer development and progression and may determine its response to therapy. NF-kB is a target for chemotherapeutic agents<ref>PMID:16673382</ref>. NF-kB is a critical link between inflammation and cancer<ref>PMID:20066113</ref>.
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</StructureSection>
==3D structures of NF-kappaB==
==3D structures of NF-kappaB==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*RelA (p65)
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**[[1bft]], [[1my5]] – mRelA dimerization domain – mouse <br />
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**[[1my7]] – mRelA dimerization domain (mutant) <br />
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**[[1ram]], [[2ram]] – mRelA residues 19-291 + DNA <br />
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**[[1k3z]], [[1oy3]] – mRelA dimerization domain + I-κ-B-α <br />
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'''RelA (p65)'''
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*NF-kB1 (p50)
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[[1bft]], [[1my5]] – mRelA dimerization domain – mouse <br />
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**[[1svc]] – hp50 + DNA - human - NMR<br />
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[[1my7]] – mRelA dimerization domain (mutant) <br />
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**[[1nfk]] – mp50 + DNA<br />
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[[1ram]], [[2ram]] – mRelA residues 19-291 + DNA <br />
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**[[1bfs]] – mp50 dimerization domain<br />
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[[1k3z]], [[1oy3]] – mRelA dimerization domain + I-κ-B-α <br />
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**[[1u36]], [[1u3j]], [[1u3y]], [[1u3z]], [[1u41]], [[1u42]] – mp50 dimerization domain (mutant)<br />
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'''NF-kB1 (p50)'''
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*NF-kB1 (p52)
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[[1svc]] – hp50 + DNA - human - NMR<br />
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**[[7cli]], [[7vup]], [[7vuq]], [[7w7l]] – hp52 + DNA <br />
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[[1nfk]] – mp50 + DNA<br />
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[[1bfs]] – mp50 dimerization domain<br />
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[[1u36]], [[1u3j]], [[1u3y]], [[1u3z]], [[1u41]], [[1u42]] – mp50 dimerization domain (mutant)<br />
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'''NF-kB1 (p105)'''
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*NF-kB1 (p105)
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[[2dbf]] – hp105 death domain<br />
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**[[2dbf]] – hp105 death domain<br />
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[[1ooa]] – mp105 + RNA<br />
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**[[1ooa]] – mp105 + RNA<br />
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'''NF-kB1 + RelA'''
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*NF-kB1 + RelA
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[[1nfi]] – hp50 + RelA + I-κ-B-α <br />
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**[[1nfi]] – hp50 + RelA + I-κ-B-α <br />
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[[1ikn]] – mp50 + RelA + I-κ-B-α <br />
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**[[1ikn]] – mp50 + RelA + I-κ-B-α <br />
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[[1vkx]], [[1le5]], [[1le9]], [[1lei]] – mp50 + RelA + DNA<br />
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**[[1vkx]], [[1le5]], [[1le9]], [[1lei]] – mp50 + RelA + DNA<br />
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[[2i9t]] – mp105 + RelA + DNA<br />
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**[[2i9t]] – mp105 + RelA + DNA<br />
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[[2v2t]] – mp50 + RelB + DNA<br />
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**[[2v2t]] – mp50 + RelB + DNA<br />
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[[2o61]] – hp105 RHR domain + RelA + DNA<br />
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**[[2o61]] – hp105 RHR domain + RelA + DNA<br />
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[[3gut]] – hp105 + RelA + DNA<br />
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**[[3gut]] – hp105 + RelA + DNA<br />
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[[3jv4]] – hp105 dimerization domain + RelB dimerization domain<br />
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**[[3jv4]] – hp105 dimerization domain + RelB dimerization domain<br />
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}}
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== References ==
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<references/>
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[[Category:Topic Page]]

Current revision

Structure of mouse NF-kB1 p50 complex with DNA (PDB entry 1nfk)

Drag the structure with the mouse to rotate

3D structures of NF-kappaB

Updated on 16-July-2023

References

  1. ↑ Hayden MS, Ghosh S. Signaling to NF-kappaB. Genes Dev. 2004 Sep 15;18(18):2195-224. PMID:15371334 doi:http://dx.doi.org/10.1101/gad.1228704
  2. ↑ Karin M. NF-kappaB and cancer: mechanisms and targets. Mol Carcinog. 2006 Jun;45(6):355-61. PMID:16673382 doi:http://dx.doi.org/10.1002/mc.20217
  3. ↑ Karin M. NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a000141. doi:, 10.1101/cshperspect.a000141. PMID:20066113 doi:http://dx.doi.org/10.1101/cshperspect.a000141

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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