2iks

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[[Image:2iks.jpg|left|200px]]<br /><applet load="2iks" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2iks, resolution 1.85&Aring;" />
 
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'''Crystal structure of N-terminal truncated DNA-binding transcriptional dual regulator from Escherichia coli K12'''<br />
 
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==About this Structure==
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==Crystal structure of N-terminal truncated DNA-binding transcriptional dual regulator from Escherichia coli K12==
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2IKS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IKS OCA].
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<StructureSection load='2iks' size='340' side='right'caption='[[2iks]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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[[Category: Escherichia coli]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2iks]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IKS FirstGlance]. <br>
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[[Category: Chang, C.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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[[Category: Edwards, A M.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[Category: Evdokimova, E.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iks OCA], [https://pdbe.org/2iks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iks RCSB], [https://www.ebi.ac.uk/pdbsum/2iks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iks ProSAT], [https://www.topsan.org/Proteins/MCSG/2iks TOPSAN]</span></td></tr>
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[[Category: Joachimiak, A.]]
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</table>
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[[Category: Kagan, O.]]
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== Function ==
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[https://www.uniprot.org/uniprot/CRA_ECOLI CRA_ECOLI] Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism. Activates transcription of genes encoding biosynthetic and oxidative enzymes (involved in Krebs cycle, glyoxylate shunt and gluconeogenesis, such as ppsA and fbp). Represses genes involved in sugar catabolism, such as fruB, pfkA, pykF and adhE. Binds asymmetrically to the two half-sites of its operator.<ref>PMID:16115199</ref> <ref>PMID:8195118</ref> <ref>PMID:8230205</ref> <ref>PMID:8550429</ref> <ref>PMID:8577250</ref> <ref>PMID:8858581</ref> <ref>PMID:9084760</ref> <ref>PMID:9371462</ref>
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[[Category: Savchenko, A.]]
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== Evolutionary Conservation ==
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[[Category: dna-binding transcriptional dual regulator]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: escherichia coli k12]]
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Check<jmol>
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[[Category: mcsg]]
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<jmolCheckbox>
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[[Category: midwest center for structural genomics]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ik/2iks_consurf.spt"</scriptWhenChecked>
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[[Category: protein structure initiative]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: psi-2]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: structural genomics]]
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iks ConSurf].
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:53:39 2008''
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli K-12]]
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[[Category: Large Structures]]
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[[Category: Chang C]]
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[[Category: Edwards AM]]
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[[Category: Evdokimova E]]
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[[Category: Joachimiak A]]
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[[Category: Kagan O]]
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[[Category: Savchenko A]]

Current revision

Crystal structure of N-terminal truncated DNA-binding transcriptional dual regulator from Escherichia coli K12

PDB ID 2iks

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