4krf

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{{STRUCTURE_4krf| PDB=4krf | SCENE= }}
 
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===Structure of Human Argonaute-1 let-7 complex===
 
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{{ABSTRACT_PUBMED_23746446}}
 
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==Function==
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==Structure of Human Argonaute-1 let-7 complex==
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[[http://www.uniprot.org/uniprot/AGO1_HUMAN AGO1_HUMAN]] Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).<ref>PMID:16289642</ref> <ref>PMID:16936728</ref> <ref>PMID:18771919</ref>
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<StructureSection load='4krf' size='340' side='right'caption='[[4krf]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4krf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KRF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.101&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4krf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4krf OCA], [https://pdbe.org/4krf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4krf RCSB], [https://www.ebi.ac.uk/pdbsum/4krf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4krf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AGO1_HUMAN AGO1_HUMAN] Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).<ref>PMID:16289642</ref> <ref>PMID:16936728</ref> <ref>PMID:18771919</ref>
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==About this Structure==
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==See Also==
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[[4krf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRF OCA].
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*[[Argonaute 3D structures|Argonaute 3D structures]]
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:023746446</ref><references group="xtra"/><references/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Elkayam, E.]]
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[[Category: Large Structures]]
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[[Category: Faehnle, C R.]]
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[[Category: Elkayam E]]
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[[Category: Joshua-Tor, L.]]
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[[Category: Faehnle CR]]
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[[Category: Eukaryotic argonaute]]
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[[Category: Joshua-Tor L]]
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[[Category: Gene regulation]]
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[[Category: Rnai]]
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[[Category: Slicer]]
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[[Category: Transcription-rna complex]]
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Current revision

Structure of Human Argonaute-1 let-7 complex

PDB ID 4krf

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