4j93

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{{STRUCTURE_4j93| PDB=4j93 | SCENE= }}
 
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===Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BI-1===
 
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{{ABSTRACT_PUBMED_23817385}}
 
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==Function==
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==Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BI-1==
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[[http://www.uniprot.org/uniprot/Q79791_9HIV1 Q79791_9HIV1]] Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).[SAAS:SAAS000071_004_008806] Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).[SAAS:SAAS000071_004_011858]
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<StructureSection load='4j93' size='340' side='right'caption='[[4j93]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4j93]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J93 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0OE:4-{2-[5-(3-CHLOROPHENYL)-1H-PYRAZOL-4-YL]-1-[3-(1H-IMIDAZOL-1-YL)PROPYL]-1H-BENZIMIDAZOL-5-YL}BENZOIC+ACID'>0OE</scene>, <scene name='pdbligand=1JR:(4S)-3-PHENYL-4-(PYRIDIN-3-YL)-4,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-6(2H)-ONE'>1JR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j93 OCA], [https://pdbe.org/4j93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j93 RCSB], [https://www.ebi.ac.uk/pdbsum/4j93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j93 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q79791_9HIV1 Q79791_9HIV1] Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).[SAAS:SAAS000071_004_008806] Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).[SAAS:SAAS000071_004_011858]
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==About this Structure==
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==See Also==
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[[4j93]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J93 OCA].
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*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]]
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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==Reference==
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__TOC__
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<ref group="xtra">PMID:023817385</ref><references group="xtra"/><references/>
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</StructureSection>
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Lemke, C T.]]
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[[Category: Large Structures]]
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[[Category: Structural protein capsid]]
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[[Category: Lemke CT]]
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[[Category: Viral protein]]
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[[Category: Viral protein-viral protein inhibitor complex]]
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Current revision

Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BI-1

PDB ID 4j93

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