3u9g

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{{STRUCTURE_3u9g| PDB=3u9g | SCENE= }}
 
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===Crystal structure of the Zinc finger antiviral protein===
 
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{{ABSTRACT_PUBMED_22407013}}
 
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==About this Structure==
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==Crystal structure of the Zinc finger antiviral protein==
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[[3u9g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U9G OCA].
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<StructureSection load='3u9g' size='340' side='right'caption='[[3u9g]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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==Reference==
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<table><tr><td colspan='2'>[[3u9g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U9G FirstGlance]. <br>
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<ref group="xtra">PMID:022407013</ref><references group="xtra"/><references/>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.801&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u9g OCA], [https://pdbe.org/3u9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u9g RCSB], [https://www.ebi.ac.uk/pdbsum/3u9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u9g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ZCCHV_RAT ZCCHV_RAT] Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1) and moloney and murine leukemia virus (MoMLV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation.<ref>PMID:12215647</ref> <ref>PMID:14557641</ref> <ref>PMID:17182693</ref> <ref>PMID:17185417</ref> <ref>PMID:17928353</ref> <ref>PMID:18225958</ref> <ref>PMID:21876179</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Chen, S.]]
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[[Category: Chen S]]
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[[Category: Gao, G.]]
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[[Category: Gao G]]
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[[Category: Liu, Y.]]
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[[Category: Liu Y]]
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[[Category: Sun, J.]]
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[[Category: Sun J]]
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[[Category: Wang, X.]]
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[[Category: Wang X]]
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[[Category: Xu, Y.]]
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[[Category: Xu Y]]
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[[Category: Zhang, K.]]
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[[Category: Zhang K]]
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[[Category: Antiviral protein]]
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[[Category: Zinc finger protein]]
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Current revision

Crystal structure of the Zinc finger antiviral protein

PDB ID 3u9g

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